QUODD

Insider: Opaleye Management Inc.

Company Holdings	All	CDXS	ETON	HROW	SNWV	TARA	TELA	OCUL

Company Holdings

All

CDXS

ETON

HROW

SNWV

TARA

TELA

OCUL

	Direct	Indirect Ownership	Total
Shares		24,211,634	24,211,634
Value	$	$164,872,209.31	$164,872,209.31

Ticker	Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
CDXS	08/04/2025	AAP	780	Indirect	COM	$2.84	$2,211.30	12,545,000
CDXS	07/31/2025	AAP	84,220	Indirect	COM	$2.68	$225,709.60	12,544,220
CDXS	07/30/2025	AAP	1,578	Indirect	COM	$2.80	$4,410.51	12,460,000
CDXS	07/29/2025	AAP	8,422	Indirect	COM	$2.82	$23,750.04	12,458,422
CDXS	07/18/2025	AAP	100,000	Indirect	COM	$2.82	$282,000.00	12,450,000
CDXS	06/27/2025	AAP	100,000	Indirect	COM	$2.39	$239,000.00	12,350,000
CDXS	06/16/2025	AAP	50,898	Indirect	COM	$2.24	$114,011.52	12,250,000
CDXS	06/13/2025	AAP	99,102	Indirect	COM	$2.23	$220,997.46	12,199,102
CDXS	06/12/2025	AAP	100,000	Indirect	COM	$2.25	$225,000.00	12,100,000
ETON	06/10/2025	AAP	5,000	Indirect	COM	$15.82	$79,119.50	2,770,000
HROW	06/10/2025	DDS	15,000	Indirect	COM	$30.80	$462,033.00	90,000
ETON	06/10/2025	AAP	2,930	Indirect	COM	$15.82	$46,364.03	85,000
HROW	06/09/2025	DDS	15,204	Indirect	COM	$30.37	$461,794.13	105,000
HROW	06/04/2025	DDS	1,796	Indirect	COM	$30.02	$53,907.48	120,204
HROW	06/03/2025	DDS	3,000	Indirect	COM	$30.04	$90,116.10	122,000
CDXS	05/28/2025	AAP	5,000	Indirect	COM	$2.36	$11,800.00	12,000,000
CDXS	05/23/2025	AAP	2,320,000	Indirect	COM	$2.36	$5,475,200.00	11,995,000
HROW	05/13/2025	DDS	5,000	Indirect	COM	$26.59	$132,945.00	125,000
HROW	05/12/2025	DDS	10,000	Indirect	COM	$25.90	$258,959.00	130,000
CDXS	05/01/2025	AAP	20,000	Indirect	COM	$2.32	$46,436.00	9,675,000
CDXS	04/30/2025	AAP	25,000	Indirect	COM	$2.31	$57,660.00	9,655,000
SNWV	04/29/2025	AAP	2,998	Indirect	COM	$25.49	$76,421.42	15,000
SNWV	04/29/2025	AAP	5,000	Indirect	COM	$25.49	$127,454.00	965,000
CDXS	04/25/2025	AAP	25,000	Indirect	COM	$2.24	$55,915.00	9,630,000
CDXS	04/17/2025	AAP	45,000	Indirect	COM	$2.09	$94,162.50	9,605,000

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Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
08/04/2025	AAP	780	Indirect	COM	$2.84	$2,211.30	12,545,000
07/31/2025	AAP	84,220	Indirect	COM	$2.68	$225,709.60	12,544,220
07/30/2025	AAP	1,578	Indirect	COM	$2.80	$4,410.51	12,460,000
07/29/2025	AAP	8,422	Indirect	COM	$2.82	$23,750.04	12,458,422
07/18/2025	AAP	100,000	Indirect	COM	$2.82	$282,000.00	12,450,000
06/27/2025	AAP	100,000	Indirect	COM	$2.39	$239,000.00	12,350,000
06/16/2025	AAP	50,898	Indirect	COM	$2.24	$114,011.52	12,250,000
06/13/2025	AAP	99,102	Indirect	COM	$2.23	$220,997.46	12,199,102
06/12/2025	AAP	100,000	Indirect	COM	$2.25	$225,000.00	12,100,000
05/28/2025	AAP	5,000	Indirect	COM	$2.36	$11,800.00	12,000,000
05/23/2025	AAP	2,320,000	Indirect	COM	$2.36	$5,475,200.00	11,995,000
05/01/2025	AAP	20,000	Indirect	COM	$2.32	$46,436.00	9,675,000
04/30/2025	AAP	25,000	Indirect	COM	$2.31	$57,660.00	9,655,000
04/25/2025	AAP	25,000	Indirect	COM	$2.24	$55,915.00	9,630,000
04/17/2025	AAP	45,000	Indirect	COM	$2.09	$94,162.50	9,605,000
04/16/2025	AAP	70,000	Indirect	COM	$2.13	$148,890.00	9,560,000
04/15/2025	AAP	25,000	Indirect	COM	$2.23	$55,720.00	9,490,000
04/08/2025	AAP	100,000	Indirect	COM	$1.98	$198,380.00	9,465,000
04/03/2025	AAP	75,000	Indirect	COM	$2.30	$172,740.00	9,365,000
04/02/2025	AAP	5,000	Indirect	COM	$2.46	$12,276.00	9,290,000
04/01/2025	AAP	35,000	Indirect	COM	$2.48	$86,772.00	9,285,000
03/21/2025	AAP	92,923	Indirect	COM	$2.54	$236,266.02	9,250,000
03/20/2025	AAP	7	Indirect	COM	$2.54	$17.97	9,157,077
03/13/2025	AAP	85,000	Indirect	COM	$2.54	$216,155.00	9,150,000
03/06/2025	AAP	100,000	Indirect	COM	$2.61	$261,350.00	9,065,000

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
06/10/2025	AAP	5,000	Indirect	COM	$15.82	$79,119.50	2,770,000
06/10/2025	AAP	2,930	Indirect	COM	$15.82	$46,364.03	85,000
10/23/2024	AAP	10,000	Indirect	COM	$7.98	$79,814.00	2,770,000
09/11/2024	AAP	45,000	Indirect	COM	$4.75	$213,750.00	2,705,000
09/11/2024	AAP	5,000	Indirect	COM	$4.75	$23,750.00	75,000
09/10/2024	AAP	50,000	Indirect	COM	$4.65	$232,500.00	2,660,000
09/10/2024	AAP	7,500	Indirect	COM	$4.65	$34,875.00	70,000
11/17/2021	DDS	25,000	Indirect	COM	$4.67	$116,712.50	2,375,000
11/16/2021	DDS	11,500	Indirect	COM	$4.86	$55,911.85	2,400,000
11/16/2021	DDS	938	Indirect	COM	$4.86	$4,560.46	85,000
11/15/2021	DDS	2,500	Indirect	COM	$4.80	$12,004.00	2,411,500
11/15/2021	DDS	500	Indirect	COM	$4.80	$2,400.80	85,938
11/08/2021	DDS	2,661	Indirect	COM	$6.10	$16,234.76	86,438
11/08/2021	DDS	50,000	Indirect	COM	$6.10	$305,050.00	2,414,000
11/05/2021	DDS	159,300	Indirect	COM	$6.30	$1,003,765.23	2,464,000
11/05/2021	DDS	8,401	Indirect	COM	$6.30	$52,935.54	89,099
11/04/2021	DDS	4,000	Indirect	COM	$6.44	$25,748.00	97,500
11/04/2021	DDS	81,700	Indirect	COM	$6.44	$525,902.90	2,623,300
11/03/2021	DDS	110,000	Indirect	COM	$6.53	$718,399.00	2,705,000
11/03/2021	DDS	6,500	Indirect	COM	$6.53	$42,450.85	101,500
10/12/2021	DDS	82,500	Indirect	COM	$5.06	$417,177.75	2,815,000
10/12/2021	DDS	4,807	Indirect	COM	$5.06	$24,307.56	117,100
10/11/2021	DDS	1,601	Indirect	COM	$5.01	$8,014.93	112,807
10/11/2021	DDS	32,500	Indirect	COM	$5.01	$162,701.50	2,897,500
10/08/2021	DDS	41,000	Indirect	COM	$5.00	$205,008.20	2,930,000

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
06/10/2025	DDS	15,000	Indirect	COM	$30.80	$462,033.00	90,000
06/09/2025	DDS	15,204	Indirect	COM	$30.37	$461,794.13	105,000
06/04/2025	DDS	1,796	Indirect	COM	$30.02	$53,907.48	120,204
06/03/2025	DDS	3,000	Indirect	COM	$30.04	$90,116.10	122,000
05/13/2025	DDS	5,000	Indirect	COM	$26.59	$132,945.00	125,000
05/12/2025	DDS	10,000	Indirect	COM	$25.90	$258,959.00	130,000
03/18/2025	DDS	5,000	Indirect	COM	$30.01	$150,055.00	140,000
03/18/2025	DDS	5,000	Indirect	COM	$29.64	$148,200.00	145,000
02/28/2025	DDS	5,000	Indirect	COM	$28.05	$140,250.00	150,000
01/22/2025	DDS	20,000	Indirect	COM	$35.59	$711,814.00	155,000
04/25/2024	AAP	20,000	Indirect	COM	$9.97	$199,400.00	3,815,000
04/24/2024	AAP	8,285	Indirect	COM	$10.15	$84,092.75	3,795,000
04/23/2024	AAP	11,715	Indirect	COM	$10.29	$120,547.35	3,786,715
04/19/2024	AAP	29,400	Indirect	COM	$10.56	$310,390.50	3,775,000
03/28/2024	AAP	50,000	Indirect	COM	$12.82	$641,000.00	3,745,600
03/20/2024	AAP	50,600	Indirect	COM	$9.65	$488,290.00	3,695,600
11/15/2023	AAP	25,000	Indirect	COM	$8.03	$200,735.00	3,645,000
09/20/2023	AAP	5,983	Indirect	COM	$14.49	$86,710.42	3,620,000
09/19/2023	AAP	14,017	Indirect	COM	$14.65	$205,365.87	3,614,017
12/14/2022	AAP	415,000	Indirect	COM	$10.52	$4,365,800.00	3,600,000
12/14/2022	AAP	16,183	Indirect	COM	$10.52	$170,245.16	175,000
09/28/2022	AAP	10,000	Indirect	COM	$9.77	$97,748.00	3,185,000
09/28/2022	AAP	1,085	Indirect	COM	$9.77	$10,605.66	158,817
04/13/2022	AAP	2,832	Indirect	COM	$6.76	$19,153.38	157,732
04/13/2022	AAP	10,000	Indirect	COM	$6.76	$67,632.00	3,175,000

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
04/29/2025	AAP	2,998	Indirect	COM	$25.49	$76,421.42	15,000
04/29/2025	AAP	5,000	Indirect	COM	$25.49	$127,454.00	965,000

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
09/12/2024	DDS	119,801	Indirect	COM	$1.71	$204,727.93	1,944,134
09/12/2024	DDS	6,500	Indirect	COM	$1.71	$11,107.85	45,000
09/11/2024	DDS	1,600	Indirect	COM	$1.71	$2,742.56	51,500
09/11/2024	DDS	31,000	Indirect	COM	$1.71	$53,137.10	2,063,935
09/10/2024	DDS	24,000	Indirect	COM	$1.77	$42,456.00	2,094,935
09/10/2024	DDS	1,500	Indirect	COM	$1.77	$2,653.50	53,100
09/09/2024	DDS	34,592	Indirect	COM	$1.89	$65,541.46	2,118,935
09/09/2024	DDS	1,900	Indirect	COM	$1.89	$3,599.93	54,600
07/01/2024	DDS	5,788	Indirect	COM	$2.12	$12,289.66	2,213,474
07/01/2024	DDS	2,500	Indirect	COM	$2.12	$5,308.25	87,500
06/25/2024	DDS	6,500	Indirect	COM	$2.26	$14,677.65	2,266,359
06/25/2024	DDS	6,225	Indirect	COM	$2.26	$14,056.67	102,471
05/31/2024	DDS	5,824	Indirect	COM	$2.90	$16,894.84	108,696
05/30/2024	DDS	9,230	Indirect	COM	$2.94	$27,113.13	114,520
05/22/2024	DDS	9,300	Indirect	COM	$3.02	$28,095.30	2,272,859
05/22/2024	DDS	500	Indirect	COM	$3.00	$1,501.05	123,750
05/21/2024	DDS	31,200	Indirect	COM	$3.06	$95,337.84	2,282,159
05/21/2024	DDS	1,800	Indirect	COM	$3.06	$5,500.26	124,250
05/17/2024	DDS	47,250	Indirect	COM	$3.33	$157,252.73	2,333,044
05/17/2024	DDS	19,685	Indirect	COM	$3.06	$60,247.91	2,313,359
05/17/2024	DDS	1,200	Indirect	COM	$3.06	$3,672.72	126,050
05/17/2024	DDS	2,750	Indirect	COM	$3.33	$9,152.28	127,250
05/10/2024	DDS	151,700	Indirect	COM	$3.11	$472,424.14	2,380,294
05/09/2024	DDS	30,600	Indirect	COM	$3.09	$94,526.46	2,531,994
12/30/2022	AAS	13,173	Indirect	COM	$2.71	$35,713.32	2,562,594

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
10/11/2022	AAP	15,000	Indirect	COM	$8.00	$120,000.00	1,929,000
10/11/2022	AAP	1,000	Indirect	COM	$8.00	$8,000.00	123,551
09/23/2022	AAP	6,500	Indirect	COM	$7.99	$51,962.30	1,914,000
09/23/2022	AAP	304	Indirect	COM	$7.99	$2,430.24	122,551
09/19/2022	AAP	17,000	Indirect	COM	$8.09	$137,496.00	1,907,500
09/19/2022	AAP	1,000	Indirect	COM	$8.09	$8,088.00	122,247
09/16/2022	AAP	2,000	Indirect	COM	$8.08	$16,166.20	1,890,500
09/16/2022	AAP	372	Indirect	COM	$8.08	$3,006.91	121,247
09/15/2022	AAP	3,500	Indirect	COM	$8.10	$28,350.00	1,888,500
09/15/2022	AAP	658	Indirect	COM	$8.10	$5,329.80	120,875
08/16/2022	AAP	5,000	Indirect	COM	$8.10	$40,495.50	1,885,000
08/16/2022	AAP	221	Indirect	COM	$8.10	$1,789.90	120,217
08/16/2022	AAP	300,000	Indirect	COM	$8.00	$2,400,000.00	1,880,000
08/16/2022	AAP	15,000	Indirect	COM	$8.00	$120,000.00	120,000
08/10/2022	AAP	11,500	Indirect	COM	$8.52	$98,006.45	1,580,000
08/10/2022	AAP	479	Indirect	COM	$8.52	$4,082.18	105,000
08/01/2022	AAP	4,500	Indirect	COM	$7.96	$35,819.10	1,565,500
08/01/2022	AAP	479	Indirect	COM	$7.96	$3,812.74	100,679
07/22/2022	AAP	5,000	Indirect	COM	$8.02	$40,105.00	1,564,000
07/22/2022	AAP	200	Indirect	COM	$8.02	$1,604.20	100,200
07/21/2022	AAP	9,500	Indirect	COM	$8.03	$76,282.15	1,559,000
07/21/2022	AAP	833	Indirect	COM	$8.08	$6,727.97	100,000
07/20/2022	AAP	4,500	Indirect	COM	$8.08	$36,345.60	1,549,500
07/20/2022	AAP	600	Indirect	COM	$8.08	$4,846.08	99,167
06/22/2022	AAP	400	Indirect	COM	$6.99	$2,796.00	97,800

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
01/02/2020	AAP	15,000	Indirect	COM	$3.90	$58,507.50	4,918,500
12/30/2019	AAP	15,000	Indirect	COM	$3.97	$59,557.50	4,903,500
12/30/2019	AAP	5,000	Indirect	COM	$3.97	$19,852.50	207,500

Transaction Type Key
First letter: A = Acquired, D = Disposed
Second letter:
A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust

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