| Transactions | |||
| All | Buy | Sell | Option Exercise |
Filer's Name |
Relationship/ Title |
Trans. Date |
Trans. Type |
Ownership Type |
Security Type |
Shares |
Price |
Trans. Value |
Total Shares Owned |
| Riedel Norbert G | Director | 02/03/2026 | AX | Direct | COM | 30,000 | $4.42 | $132,600.00 | 35,000 |
| Gruber James R. | Chief Financial Officer | 01/14/2026 | DF | Direct | COM | 2,293 | $15.47 | $35,472.71 | 213,420 |
| Krempa David | Chief Business Officer | 01/14/2026 | DF | Direct | COM | 1,942 | $15.62 | $30,334.04 | 630,238 |
| Brynjelsen Sean | President & CEO | 01/01/2026 | DF | Direct | COM | 5,015 | $15.39 | $77,180.85 | 2,889,266 |
| Brynjelsen Sean | President & CEO | 12/12/2025 | DF | Direct | COM | 6,732 | $16.83 | $113,299.56 | 2,894,281 |
| Gruber James R. | Chief Financial Officer | 12/12/2025 | DF | Direct | COM | 4,542 | $16.99 | $77,168.58 | 215,713 |
| Krempa David | Chief Business Officer | 12/12/2025 | DF | Direct | COM | 6,264 | $17.00 | $106,488.00 | 632,180 |
| Erdogan-Trinkaus Ipek | Chief Commercial Officer | 12/12/2025 | DF | Direct | COM | 85 | $16.90 | $1,436.50 | 2,403 |
| Gruber James R. | Chief Financial Officer | 08/20/2025 | DS | Direct | COM | 2,631 | $16.02 | $42,148.62 | 204,753 |
| Gruber James R. | Chief Financial Officer | 08/19/2025 | DS | Direct | COM | 39,082 | $16.16 | $631,565.12 | 205,299 |
| Krempa David | Chief Business Officer | 06/16/2025 | DS | Direct | COM | 10,223 | $14.73 | $150,584.79 | 612,646 |
| Krempa David | Chief Business Officer | 06/13/2025 | DS | Direct | COM | 6,800 | $14.77 | $100,436.00 | 622,869 |
| Krempa David | Chief Business Officer | 06/12/2025 | DS | Direct | COM | 16,977 | $14.92 | $253,296.84 | 629,669 |
| Opaleye Management Inc. | Other | 06/10/2025 | AP | Indirect | COM | 2,930 | $15.82 | $46,364.03 | 85,000 |
| Opaleye Management Inc. | Other | 06/10/2025 | AP | Indirect | COM | 5,000 | $15.82 | $79,119.50 | 2,770,000 |
| Brynjelsen Sean | President & CEO | 06/05/2025 | DS | Direct | COM | 70,000 | $16.81 | $1,176,700.00 | 2,873,513 |
| Brynjelsen Sean | President & CEO | 06/04/2025 | DS | Direct | COM | 70,000 | $17.00 | $1,190,000.00 | 2,943,513 |
| Brynjelsen Sean | President & CEO | 06/03/2025 | DS | Direct | COM | 400 | $19.02 | $7,608.00 | 3,013,513 |
| Brynjelsen Sean | President & CEO | 06/03/2025 | DS | Direct | COM | 8,655 | $18.38 | $159,078.90 | 3,013,913 |
| Brynjelsen Sean | President & CEO | 06/03/2025 | DS | Direct | COM | 60,945 | $17.38 | $1,059,224.10 | 3,022,568 |
| Riedel Norbert G | Director | 01/03/2025 | AM | Direct | COM | 25,000 | $3.47 | $86,750.00 | 162,145 |
| Riedel Norbert G | Director | 01/03/2025 | AM | Direct | COM | 50,000 | $3.78 | $189,000.00 | 137,145 |
| Riedel Norbert G | Director | 01/03/2025 | AM | Direct | COM | 27,400 | $3.58 | $98,092.00 | 87,145 |
| Opaleye Management Inc. | Other | 10/23/2024 | AP | Indirect | COM | 10,000 | $7.98 | $79,814.00 | 2,770,000 |
| Opaleye Management Inc. | Other | 09/11/2024 | AP | Indirect | COM | 5,000 | $4.75 | $23,750.00 | 75,000 |
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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust |
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