QUODD

Insider: EcoR1 Capital, LLC

Company Holdings	All	ADAP	ZYME	PRTA	TNGX	ANAB	VYGR	CRVS

Company Holdings

All

ADAP

ZYME

PRTA

TNGX

ANAB

VYGR

CRVS

	Direct	Indirect Ownership	Total
Shares		147,061,826	147,061,826
Value	$	$633,330,159.49	$633,330,159.49

Ticker	Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
ADAP	07/30/2025	DDS	27,433,338	Indirect	COM	$0.10	$2,800,943.81	100,371,882
ADAP	07/29/2025	DDS	2,687,460	Indirect	COM	$0.10	$271,970.95	127,805,220
ADAP	07/28/2025	DDS	33,931,740	Indirect	COM	$0.11	$3,817,320.75	130,492,680
ZYME	05/19/2025	AAP	5,919	Indirect	COM	$11.78	$69,738.25	17,883,908
ZYME	05/15/2025	AAP	49,502	Indirect	COM	$11.43	$565,847.46	17,877,989
PRTA	05/06/2025	DDS	1,984,053	Indirect	COM	$7.64	$15,164,712.29	5,304,596
PRTA	05/05/2025	DDS	977,693	Indirect	COM	$8.11	$7,930,165.69	7,288,649
PRTA	05/02/2025	DDS	3,317,938	Indirect	COM	$8.36	$27,744,929.35	8,266,342
ZYME	04/17/2025	AAP	54,760	Indirect	COM	$11.52	$630,818.77	17,828,487
ZYME	04/16/2025	AAP	73,953	Indirect	COM	$11.16	$825,589.11	17,773,727
ZYME	04/04/2025	AAP	196,438	Indirect	COM	$11.17	$2,193,799.94	17,699,774
ZYME	04/03/2025	AAP	120,770	Indirect	COM	$11.84	$1,430,170.42	17,503,336
ZYME	04/02/2025	AAP	74,360	Indirect	COM	$11.85	$881,017.28	17,382,566
ZYME	04/01/2025	AAP	48,658	Indirect	COM	$11.60	$564,646.90	17,308,206
ZYME	03/31/2025	AAP	4,397	Indirect	COM	$11.75	$51,658.15	17,259,548
ZYME	03/26/2025	AAP	43,848	Indirect	COM	$12.24	$536,857.37	17,255,151
ZYME	03/25/2025	AAP	53,501	Indirect	COM	$12.91	$690,451.81	17,211,303
ZYME	03/24/2025	AAP	22,689	Indirect	COM	$13.08	$296,846.99	17,157,802
ZYME	03/21/2025	AAP	31,033	Indirect	COM	$12.78	$396,517.95	17,135,113
ZYME	03/20/2025	AAP	73,476	Indirect	COM	$12.93	$949,883.03	17,104,080
ZYME	03/19/2025	AAP	58,306	Indirect	COM	$12.64	$737,232.73	17,030,604
ZYME	03/18/2025	AAP	113,880	Indirect	COM	$12.65	$1,440,855.31	16,972,298
ZYME	03/17/2025	AAP	56,277	Indirect	COM	$12.23	$688,464.68	16,858,418
ZYME	03/13/2025	AAP	468,356	Indirect	COM	$12.48	$5,847,237.32	16,802,141
ZYME	03/12/2025	AAP	292,934	Indirect	COM	$12.25	$3,587,826.34	16,333,785

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Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
07/30/2025	DDS	27,433,338	Indirect	COM	$0.10	$2,800,943.81	100,371,882
07/29/2025	DDS	2,687,460	Indirect	COM	$0.10	$271,970.95	127,805,220
07/28/2025	DDS	33,931,740	Indirect	COM	$0.11	$3,817,320.75	130,492,680

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
05/19/2025	AAP	5,919	Indirect	COM	$11.78	$69,738.25	17,883,908
05/15/2025	AAP	49,502	Indirect	COM	$11.43	$565,847.46	17,877,989
04/17/2025	AAP	54,760	Indirect	COM	$11.52	$630,818.77	17,828,487
04/16/2025	AAP	73,953	Indirect	COM	$11.16	$825,589.11	17,773,727
04/04/2025	AAP	196,438	Indirect	COM	$11.17	$2,193,799.94	17,699,774
04/03/2025	AAP	120,770	Indirect	COM	$11.84	$1,430,170.42	17,503,336
04/02/2025	AAP	74,360	Indirect	COM	$11.85	$881,017.28	17,382,566
04/01/2025	AAP	48,658	Indirect	COM	$11.60	$564,646.90	17,308,206
03/31/2025	AAP	4,397	Indirect	COM	$11.75	$51,658.15	17,259,548
03/26/2025	AAP	43,848	Indirect	COM	$12.24	$536,857.37	17,255,151
03/25/2025	AAP	53,501	Indirect	COM	$12.91	$690,451.81	17,211,303
03/24/2025	AAP	22,689	Indirect	COM	$13.08	$296,846.99	17,157,802
03/21/2025	AAP	31,033	Indirect	COM	$12.78	$396,517.95	17,135,113
03/20/2025	AAP	73,476	Indirect	COM	$12.93	$949,883.03	17,104,080
03/19/2025	AAP	58,306	Indirect	COM	$12.64	$737,232.73	17,030,604
03/18/2025	AAP	113,880	Indirect	COM	$12.65	$1,440,855.31	16,972,298
03/17/2025	AAP	56,277	Indirect	COM	$12.23	$688,464.68	16,858,418
03/13/2025	AAP	468,356	Indirect	COM	$12.48	$5,847,237.32	16,802,141
03/12/2025	AAP	292,934	Indirect	COM	$12.25	$3,587,826.34	16,333,785
03/11/2025	AAP	320,690	Indirect	COM	$11.49	$3,685,850.52	16,040,851
01/17/2025	AAP	19,748	Indirect	COM	$13.87	$273,997.58	15,720,161
01/16/2025	AAP	121,681	Indirect	COM	$13.89	$1,689,540.69	15,700,413
01/15/2025	AAP	39,029	Indirect	COM	$14.01	$546,671.40	15,578,732
01/14/2025	AAP	54,500	Indirect	COM	$13.56	$739,265.25	15,539,703
01/13/2025	AAP	74,125	Indirect	COM	$13.39	$992,874.73	15,485,203

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
05/06/2025	DDS	1,984,053	Indirect	COM	$7.64	$15,164,712.29	5,304,596
05/05/2025	DDS	977,693	Indirect	COM	$8.11	$7,930,165.69	7,288,649
05/02/2025	DDS	3,317,938	Indirect	COM	$8.36	$27,744,929.35	8,266,342
05/05/2022	DDS	1,062,736	Indirect	COM	$29.02	$30,840,598.72	11,584,280
05/05/2022	AAP	1,062,736	Indirect	COM	$29.02	$30,840,598.72	11,584,280
01/12/2022	AAP	300,000	Indirect	COM	$37.50	$11,250,300.00	11,584,280
03/24/2021	AAP	875,000	Indirect	COM	$20.75	$18,156,250.00	11,034,280
02/24/2021	AAP	10,800	Indirect	COM	$22.02	$237,866.76	10,159,280
02/23/2021	AAP	44,400	Indirect	COM	$21.05	$934,517.88	10,148,480
02/17/2021	AAP	198,840	Indirect	COM	$23.46	$4,665,541.99	10,059,980
02/16/2021	AAP	89,200	Indirect	COM	$22.78	$2,031,967.08	9,861,140
02/12/2021	AAP	62,500	Indirect	COM	$20.50	$1,281,250.00	9,489,140
02/12/2021	AAP	282,800	Indirect	COM	$20.08	$5,678,510.88	9,771,940

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
11/07/2024	DDS	62,318	Indirect	COM	$3.29	$205,113.47	11,773,860
11/07/2024	DDS	1,143,124	Indirect	COM	$2.92	$3,334,607.02	10,630,736
11/06/2024	DDS	1,494,558	Indirect	COM	$3.28	$4,896,022.55	11,836,178

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
08/14/2024	AAP	273,972	Indirect	COM	$36.50	$9,999,978.00	7,794,996
05/05/2022	AAP	668,237	Indirect	COM	$21.63	$14,453,966.31	7,521,024
05/05/2022	DDS	668,237	Indirect	COM	$21.63	$14,453,966.31	7,521,024
05/04/2021	AAP	165,000	Indirect	COM	$23.25	$3,835,755.00	7,520,424
05/03/2021	AAP	20,800	Indirect	COM	$23.31	$484,872.96	7,355,424
04/30/2021	AAP	35,700	Indirect	COM	$23.16	$826,815.57	7,334,624
04/27/2021	AAP	33,800	Indirect	COM	$23.82	$805,088.96	7,298,924
04/26/2021	AAP	13,900	Indirect	COM	$23.80	$330,858.92	7,265,124
04/23/2021	AAP	99,600	Indirect	COM	$23.54	$2,344,285.20	7,251,224
03/09/2021	AAP	531,000	Indirect	COM	$18.70	$9,928,425.60	7,151,624
03/08/2021	AAP	2,777,800	Indirect	COM	$18.97	$52,694,310.44	6,620,624
02/23/2021	AAP	29,500	Indirect	COM	$25.48	$751,657.05	3,842,824

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
01/11/2023	DDS	110,000	Indirect	COM	$8.50	$934,615.00	3,851,507
01/10/2023	DDS	336,400	Indirect	COM	$8.05	$2,709,432.88	3,961,507
01/09/2023	DDS	456,000	Indirect	COM	$7.67	$3,498,295.20	4,297,907

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
10/01/2021	DDS	2,000,000	Indirect	COM	$4.96	$9,928,800.00	81,077
09/30/2021	DDS	3,000,000	Indirect	COM	$5.04	$15,131,100.00	2,081,077

Transaction Type Key
First letter: A = Acquired, D = Disposed
Second letter:
A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust

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