| Transactions | |||
| All | Buy | Sell | Option Exercise |
Filer's Name |
Relationship/ Title |
Trans. Date |
Trans. Type |
Ownership Type |
Security Type |
Shares |
Price |
Trans. Value |
Total Shares Owned |
| Thompson Peter A. | Director | 01/28/2026 | AM | Direct | COM | 15,000 | $2.12 | $31,800.00 | 210,000 |
| Thompson Peter A. | Director | 01/28/2026 | AM | Direct | COM | 15,000 | $1.64 | $24,600.00 | 195,000 |
| Thompson Peter A. | Director | 01/28/2026 | AM | Direct | COM | 15,000 | $2.49 | $37,350.00 | 180,000 |
| Thompson Peter A. | Director | 01/28/2026 | AM | Direct | COM | 15,000 | $0.97 | $14,475.00 | 165,000 |
| Thompson Peter A. | Director | 01/28/2026 | AM | Direct | COM | 15,000 | $0.99 | $14,848.50 | 150,000 |
| Thompson Peter A. | Director | 01/28/2026 | AM | Direct | COM | 15,000 | $2.60 | $39,000.00 | 135,000 |
| Thompson Peter A. | Director | 01/28/2026 | AM | Direct | COM | 15,000 | $2.74 | $41,100.00 | 120,000 |
| Thompson Peter A. | Director | 01/28/2026 | AM | Direct | COM | 15,000 | $3.27 | $49,050.00 | 105,000 |
| Thompson Peter A. | Director | 01/28/2026 | AM | Direct | COM | 15,000 | $2.00 | $30,000.00 | 90,000 |
| Thompson Peter A. | Director | 01/28/2026 | AM | Direct | COM | 15,000 | $3.61 | $54,150.00 | 75,000 |
| Thompson Peter A. | Director | 01/28/2026 | AM | Direct | COM | 15,000 | $12.50 | $187,500.00 | 60,000 |
| Thompson Peter A. | Director | 01/28/2026 | AM | Direct | COM | 15,000 | $9.70 | $145,500.00 | 45,000 |
| Thompson Peter A. | Director | 01/28/2026 | AM | Direct | COM | 30,000 | $15.00 | $450,000.00 | 30,000 |
| Thompson Peter A. | Director | 06/27/2025 | DS | Indirect | COM | 1,176,332 | $4.16 | $4,891,894.26 | 7,165,006 |
| Thompson Peter A. | Director | 06/27/2025 | AX | Indirect | COM | 1,397,684 | $3.50 | $4,891,894.00 | 8,341,338 |
| Orbimed Advisors Llc | Director | 06/27/2025 | DS | Indirect | COM | 1,176,332 | $4.16 | $4,891,894.26 | 7,165,006 |
| Orbimed Advisors Llc | Director | 06/27/2025 | AX | Indirect | COM | 1,397,684 | $3.50 | $4,891,894.00 | 8,341,338 |
| Jones William Benton | See Remarks | 06/04/2025 | AM | Direct | COM | 19,357 | $3.50 | $67,749.50 | 173,130 |
| Miller Richard A Md | President and CEO | 05/07/2025 | AM | Direct | COM | 559,073 | $3.50 | $1,956,755.50 | 1,136,707 |
| Miller Richard A Md | President and CEO | 05/10/2024 | DG | Indirect | COM | 302,016 | $0.00 | $0.00 | 1,188,103 |
| Miller Richard A Md | President and CEO | 05/06/2024 | AP | Direct | COM | 577,634 | $1.73 | $999,999.98 | 577,634 |
| Jones William Benton | See Remarks | 05/06/2024 | AP | Direct | COM | 20,000 | $1.73 | $34,624.00 | 153,773 |
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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust |
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