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Insider: FROST PHILLIP MD ET AL

Company Holdings	All	OPK	BCDA	FLNT	COCP	NIMU	COGT	SFES	PLX	NOC

Company Holdings

All

OPK

BCDA

FLNT

COCP

NIMU

COGT

SFES

PLX

NOC

	Direct	Indirect Ownership	Total
Shares		292,873,814	292,873,814
Value	$	$640,052,626.83	$640,052,626.83

Ticker	Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
OPK	08/08/2025	AAP	675,000	Indirect	COM	$1.32	$891,000.00	214,676,448
OPK	04/10/2025	AAP	125,000	Indirect	COM	$1.36	$169,712.50	214,001,448
OPK	04/08/2025	AAP	125,000	Indirect	COM	$1.48	$184,650.00	213,876,448
OPK	04/01/2025	AAP	100,000	Indirect	COM	$1.65	$164,850.00	213,751,448
OPK	03/28/2025	AAP	150,000	Indirect	COM	$1.70	$254,385.00	213,651,448
OPK	03/17/2025	AAP	200,000	Indirect	COM	$1.74	$347,820.00	213,501,448
OPK	01/28/2025	AAP	47,537	Indirect	COM	$1.47	$70,060.03	213,234,014
OPK	01/17/2025	AAP	150,000	Indirect	COM	$1.47	$220,425.00	213,186,477
OPK	01/15/2025	AAP	500,000	Indirect	COM	$1.48	$740,850.00	213,036,477
OPK	12/13/2024	AAP	125,000	Indirect	COM	$1.60	$199,375.00	212,536,477
OPK	12/11/2024	AAP	500,000	Indirect	COM	$1.56	$781,050.00	212,411,477
OPK	11/29/2024	AAP	199,072	Indirect	COM	$1.53	$305,376.45	211,911,477
OPK	11/22/2024	AAP	100,000	Indirect	COM	$1.59	$159,000.00	211,712,405
OPK	11/14/2024	AAP	100,000	Indirect	COM	$1.62	$161,980.00	211,612,405
OPK	11/08/2024	AAP	280,183	Indirect	COM	$1.50	$421,535.32	211,512,405
OPK	05/23/2024	AAP	99,230	Indirect	COM	$1.27	$125,962.56	211,231,452
OPK	05/23/2024	AAP	770	Indirect	COM	$1.27	$974.05	211,232,222
OPK	05/17/2024	AAP	163,997	Indirect	COM	$1.29	$211,195.34	211,132,222
OPK	03/18/2024	AAP	500,000	Indirect	COM	$0.87	$437,100.00	210,968,225
OPK	03/14/2024	AAP	500,000	Indirect	COM	$0.89	$444,300.00	210,468,225
OPK	03/13/2024	AAP	500,000	Indirect	COM	$0.93	$463,750.00	209,968,225
OPK	03/12/2024	AAP	600,000	Indirect	COM	$0.93	$559,380.00	209,468,225
OPK	02/28/2024	AAP	500,000	Indirect	COM	$0.99	$496,150.00	208,868,225
OPK	02/21/2024	AAP	1,000,000	Indirect	COM	$0.99	$991,700.00	208,368,225
OPK	02/07/2024	AAP	1,500,000	Indirect	COM	$0.98	$1,462,800.00	207,368,225

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Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
08/08/2025	AAP	675,000	Indirect	COM	$1.32	$891,000.00	214,676,448
04/10/2025	AAP	125,000	Indirect	COM	$1.36	$169,712.50	214,001,448
04/08/2025	AAP	125,000	Indirect	COM	$1.48	$184,650.00	213,876,448
04/01/2025	AAP	100,000	Indirect	COM	$1.65	$164,850.00	213,751,448
03/28/2025	AAP	150,000	Indirect	COM	$1.70	$254,385.00	213,651,448
03/17/2025	AAP	200,000	Indirect	COM	$1.74	$347,820.00	213,501,448
01/28/2025	AAP	47,537	Indirect	COM	$1.47	$70,060.03	213,234,014
01/17/2025	AAP	150,000	Indirect	COM	$1.47	$220,425.00	213,186,477
01/15/2025	AAP	500,000	Indirect	COM	$1.48	$740,850.00	213,036,477
12/13/2024	AAP	125,000	Indirect	COM	$1.60	$199,375.00	212,536,477
12/11/2024	AAP	500,000	Indirect	COM	$1.56	$781,050.00	212,411,477
11/29/2024	AAP	199,072	Indirect	COM	$1.53	$305,376.45	211,911,477
11/22/2024	AAP	100,000	Indirect	COM	$1.59	$159,000.00	211,712,405
11/14/2024	AAP	100,000	Indirect	COM	$1.62	$161,980.00	211,612,405
11/08/2024	AAP	280,183	Indirect	COM	$1.50	$421,535.32	211,512,405
05/23/2024	AAP	99,230	Indirect	COM	$1.27	$125,962.56	211,231,452
05/23/2024	AAP	770	Indirect	COM	$1.27	$974.05	211,232,222
05/17/2024	AAP	163,997	Indirect	COM	$1.29	$211,195.34	211,132,222
03/18/2024	AAP	500,000	Indirect	COM	$0.87	$437,100.00	210,968,225
03/14/2024	AAP	500,000	Indirect	COM	$0.89	$444,300.00	210,468,225
03/13/2024	AAP	500,000	Indirect	COM	$0.93	$463,750.00	209,968,225
03/12/2024	AAP	600,000	Indirect	COM	$0.93	$559,380.00	209,468,225
02/28/2024	AAP	500,000	Indirect	COM	$0.99	$496,150.00	208,868,225
02/21/2024	AAP	1,000,000	Indirect	COM	$0.99	$991,700.00	208,368,225
02/07/2024	AAP	1,500,000	Indirect	COM	$0.98	$1,462,800.00	207,368,225

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
01/19/2024	DDS	129,802	Indirect	COM	$0.43	$55,814.86	1,896,025
12/16/2022	AAP	595,238	Indirect	COM	$1.68	$999,999.84	2,025,827
12/24/2018	AAP	2,000,000	Indirect	COM	$0.75	$1,500,000.00	12,875,318
12/21/2016	DDS	19,230,769	Indirect	COM	$0.13	$2,499,999.97	130,503,835

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
09/19/2023	AAP	100,000	Indirect	COM	$0.46	$46,000.00	18,834,874

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
04/04/2023	AAP	1,015,229	Indirect	COM	$1.97	$2,000,001.13	1,319,838
03/15/2016	AAP	2,941,177	Indirect	COM	$0.51	$1,500,000.27	106,500,147
03/25/2015	AAP	3,464,855	Indirect	COM	$0.92	$3,187,666.60	103,558,969
12/15/2014	AAP	10,000	Indirect	COM	$0.44	$4,350.00	12,367,725
12/15/2014	AAP	6,127	Indirect	COM	$0.43	$2,603.98	12,348,852
12/15/2014	AAP	8,873	Indirect	COM	$0.43	$3,815.39	12,357,725
08/12/2014	AAP	66,200	Indirect	COM	$0.29	$19,396.60	12,342,725
08/11/2014	AAP	45,000	Indirect	COM	$0.29	$13,009.50	12,276,525

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
12/21/2018	AAP	7,142,857	Indirect	COM	$0.07	$499,999.99	22,142,857
12/21/2018	AAP	26,212,468	Indirect	COM	$0.07	$1,834,872.76	48,355,325
04/08/2013	AAP	2,000,000	Indirect	COM	$0.05	$100,000.00	15,000,000
02/28/2012	AAP	1,500,000	Indirect	COM	$0.05	$75,000.00	13,000,000
12/24/2009	AAP	100,000	Indirect	COM	$0.29	$29,000.00	11,500,000

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
12/08/2017	AAP	10,000	Indirect	COM	$3.95	$39,500.00	15,734,874
11/15/2017	AAP	20,000	Indirect	COM	$4.11	$82,200.00	15,724,874
11/07/2016	AAP	10,000	Indirect	COM	$3.68	$36,800.00	15,704,874
11/04/2016	AAP	25,000	Indirect	COM	$2.97	$74,250.00	15,694,874
10/25/2016	AAP	5,000	Indirect	COM	$3.42	$17,103.00	15,669,874
10/19/2016	AAP	25,000	Indirect	COM	$3.46	$86,550.00	15,664,874

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
02/17/2012	AAP	4,500,000	Indirect	COM	$0.40	$1,800,000.00	10,478,735
02/22/2008	AAP	2,000	Indirect	COM	$3.50	$7,000.00	4,030,065

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
09/10/2009	DDS	4,179	Indirect	COM	$7.37	$30,799.23	7,728,241
09/10/2009	DDS	5,821	Indirect	COM	$7.35	$42,784.35	7,732,420
09/10/2009	DDS	9,254	Indirect	COM	$7.38	$68,294.52	7,718,987
09/10/2009	DDS	1,600	Indirect	COM	$7.39	$11,824.00	7,717,387
09/10/2009	DDS	1,700	Indirect	COM	$7.53	$12,801.00	7,613,441
09/10/2009	DDS	13,200	Indirect	COM	$7.40	$97,680.00	7,704,187
09/10/2009	DDS	1,100	Indirect	COM	$7.52	$8,272.00	7,615,141
09/10/2009	DDS	2,300	Indirect	COM	$7.54	$17,342.00	7,611,141
09/10/2009	DDS	974	Indirect	COM	$7.55	$7,353.70	7,610,167
09/10/2009	DDS	1,800	Indirect	COM	$7.45	$13,410.00	7,636,207
09/10/2009	DDS	3,716	Indirect	COM	$7.48	$27,795.68	7,629,291
09/10/2009	DDS	8,284	Indirect	COM	$7.41	$61,384.44	7,695,903
09/10/2009	DDS	750	Indirect	COM	$7.51	$5,632.50	7,616,241
09/10/2009	DDS	3,200	Indirect	COM	$7.47	$23,904.00	7,633,007
09/10/2009	DDS	12,300	Indirect	COM	$7.50	$92,250.00	7,616,991
09/10/2009	DDS	50,900	Indirect	COM	$7.44	$378,696.00	7,638,007
09/10/2009	DDS	1,400	Indirect	COM	$7.42	$10,388.00	7,694,503
09/10/2009	DDS	5,596	Indirect	COM	$7.43	$41,578.28	7,688,907
09/09/2009	DDS	2,500	Indirect	COM	$7.54	$18,850.00	7,758,465
09/09/2009	DDS	3,845	Indirect	COM	$7.53	$28,952.85	7,760,965
09/09/2009	DDS	400	Indirect	COM	$7.55	$3,020.00	7,758,065
09/09/2009	DDS	1,216	Indirect	COM	$7.62	$9,265.92	7,738,241
09/09/2009	DDS	23,431	Indirect	COM	$7.52	$176,201.12	7,764,810
09/09/2009	DDS	912	Indirect	COM	$7.60	$6,931.20	7,746,375
09/09/2009	DDS	6,918	Indirect	COM	$7.61	$52,645.98	7,739,457

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
08/05/2008	AAP	10,000	Indirect	COM	$66.69	$666,916.00	61,922
04/29/2008	AAP	10,000	Indirect	COM	$74.37	$743,690.00	51,922

Transaction Type Key
First letter: A = Acquired, D = Disposed
Second letter:
A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust

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