| Transactions | |||
| All | Buy | Sell | Option Exercise |
Filer's Name |
Relationship/ Title |
Trans. Date |
Trans. Type |
Ownership Type |
Security Type |
Shares |
Price |
Trans. Value |
Total Shares Owned |
| Fairmount Funds Management Llc | Director | 03/31/2026 | DS | Indirect | COM | 7,000,000 | $34.66 | $242,620,000.00 | 5,503,418 |
| Fairmount Funds Management Llc | Director | 03/31/2026 | AC | Indirect | COM | 7,000,000 | $0.00 | $0.00 | 12,503,418 |
| Fairmount Funds Management Llc | Director | 01/22/2026 | DS | Indirect | COM | 3,500,000 | $36.40 | $127,400,000.00 | 5,503,418 |
| Robinson John Edward | Chief Scientific Officer | 12/26/2025 | DS | Direct | COM | 90,000 | $38.74 | $3,486,600.00 | 140,002 |
| Sachs Jessica | Chief Medical Officer | 12/26/2025 | DS | Direct | COM | 82,642 | $38.70 | $3,198,245.40 | 133,938 |
| Green John L. | Chief Financial Officer | 12/26/2025 | DS | Direct | COM | 77,000 | $38.68 | $2,978,360.00 | 131,834 |
| Kearns Evan | Chief Legal Officer | 12/26/2025 | DS | Direct | COM | 65,000 | $38.70 | $2,515,500.00 | 109,398 |
| Green John L. | Chief Financial Officer | 12/17/2025 | DF | Direct | COM | 145,007 | $39.45 | $5,720,526.15 | 208,834 |
| Green John L. | Chief Financial Officer | 12/17/2025 | AA | Direct | COM | 300,000 | $0.00 | $0.00 | 353,841 |
| Green John L. | Chief Financial Officer | 12/17/2025 | AA | Direct | COM | 50,000 | $0.00 | $0.00 | 53,841 |
| Kearns Evan | Chief Legal Officer | 12/17/2025 | DF | Direct | COM | 125,602 | $39.45 | $4,954,998.90 | 174,398 |
| Kearns Evan | Chief Legal Officer | 12/17/2025 | AA | Direct | COM | 260,000 | $0.00 | $0.00 | 300,000 |
| Kearns Evan | Chief Legal Officer | 12/17/2025 | AA | Direct | COM | 40,000 | $0.00 | $0.00 | 40,000 |
| Sachs Jessica | Chief Medical Officer | 12/17/2025 | DF | Direct | COM | 154,716 | $39.45 | $6,103,546.20 | 216,580 |
| Sachs Jessica | Chief Medical Officer | 12/17/2025 | AA | Direct | COM | 320,000 | $0.00 | $0.00 | 371,296 |
| Sachs Jessica | Chief Medical Officer | 12/17/2025 | AA | Direct | COM | 50,000 | $0.00 | $0.00 | 51,296 |
| Pinnow Cole | Chief Commercial Officer | 12/17/2025 | DF | Direct | COM | 94,800 | $39.45 | $3,739,860.00 | 216,650 |
| Pinnow Cole | Chief Commercial Officer | 12/17/2025 | AA | Direct | COM | 214,000 | $0.00 | $0.00 | 311,450 |
| Pinnow Cole | Chief Commercial Officer | 12/17/2025 | AA | Direct | COM | 50,000 | $0.00 | $0.00 | 97,450 |
| Robbins Andrew R | President and CEO | 12/17/2025 | DF | Direct | COM | 367,497 | $39.45 | $14,497,756.65 | 657,503 |
| Robbins Andrew R | President and CEO | 12/17/2025 | AA | Direct | COM | 840,000 | $0.00 | $0.00 | 1,025,000 |
| Robbins Andrew R | President and CEO | 12/17/2025 | AA | Direct | COM | 185,000 | $0.00 | $0.00 | 185,000 |
| Robinson John Edward | Chief Scientific Officer | 12/17/2025 | DF | Direct | COM | 139,998 | $39.45 | $5,522,921.10 | 230,002 |
| Robinson John Edward | Chief Scientific Officer | 12/17/2025 | AA | Direct | COM | 320,000 | $0.00 | $0.00 | 370,000 |
| Robinson John Edward | Chief Scientific Officer | 12/17/2025 | AA | Direct | COM | 50,000 | $0.00 | $0.00 | 50,000 |
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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust |
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