| Transactions | |||
| All | Buy | Sell | Option Exercise |
Filer's Name |
Relationship/ Title |
Trans. Date |
Trans. Type |
Ownership Type |
Security Type |
Shares |
Price |
Trans. Value |
Total Shares Owned |
| Schallenberger Mark A. | Chief Operating Officer | 02/15/2026 | DF | Direct | COM | 7,709 | $0.58 | $4,471.22 | 663,157 |
| Neils Scott C | CFO and Assistant Secretary | 01/15/2026 | DF | Direct | COM | 8,084 | $0.65 | $5,254.60 | 843,381 |
| Bakewell John K | Director | 11/15/2025 | AA | Direct | COM | 158,228 | $0.00 | $0.00 | 158,228 |
| Lipschultz Tyler | Director | 11/15/2025 | AA | Direct | COM | 158,228 | $0.00 | $0.00 | 158,228 |
| Vizirgianakis Stavros G. | Director | 11/15/2025 | AA | Direct | COM | 553,797 | $0.00 | $0.00 | 7,515,570 |
| Browne Sean E | President and CEO | 11/15/2025 | AA | Direct | COM | 394,937 | $0.00 | $0.00 | 2,575,274 |
| Neils Scott C | CFO and Assistant Secretary | 11/15/2025 | AA | Direct | COM | 263,291 | $0.00 | $0.00 | 851,465 |
| Schallenberger Mark A. | Chief Operating Officer | 11/15/2025 | AA | Direct | COM | 292,253 | $0.00 | $0.00 | 670,866 |
| Beeson Jonn R. | Director | 11/15/2025 | AA | Direct | COM | 158,228 | $0.00 | $0.00 | 517,619 |
| Jain Abhinav | Director | 11/15/2025 | AA | Direct | COM | 158,228 | $0.00 | $0.00 | 158,228 |
| Neils Scott C | CFO | 08/15/2025 | DF | Direct | COM | 34,131 | $0.63 | $21,502.53 | 588,174 |
| Browne Sean E | President and CEO | 08/15/2025 | DF | Direct | COM | 10,605 | $0.63 | $6,681.15 | 2,180,337 |
| Orbimed Advisors Llc | Other | 04/10/2025 | DS | Indirect | COM | 17,109,618 | $0.42 | $7,186,039.56 | 0 |
| Orbimed Advisors Llc | Other | 04/10/2025 | DS | Indirect | COM | 56,004,974 | $0.42 | $23,522,089.08 | 0 |
| Neils Scott C | Chief Financial Officer | 01/15/2025 | DF | Direct | COM | 7,986 | $0.53 | $4,232.58 | 622,305 |
| Browne Sean E | President and CEO | 10/15/2024 | DF | Direct | COM | 105,442 | $0.59 | $62,210.78 | 2,190,942 |
| Browne Sean E | President and CEO | 08/15/2024 | DF | Direct | COM | 10,606 | $0.60 | $6,363.60 | 2,296,384 |
| Neils Scott C | Chief Financial Officer | 08/15/2024 | DF | Direct | COM | 34,132 | $0.60 | $20,479.20 | 630,291 |
| Brandt Kevin D | Chief Commercial Officer | 08/15/2024 | DF | Direct | COM | 56,333 | $0.60 | $33,799.80 | 943,736 |
| Bakewell John K | Director | 08/15/2024 | AA | Direct | COM | 162,162 | $0.00 | $0.00 | 755,888 |
| Beeson Jonn R. | Director | 08/15/2024 | AA | Direct | COM | 162,162 | $0.00 | $0.00 | 359,391 |
| Mcnamara Robert | Director | 08/15/2024 | AA | Direct | COM | 162,162 | $0.00 | $0.00 | 754,151 |
| Mitchell-Keller Lori D | Director | 08/15/2024 | AA | Direct | COM | 162,162 | $0.00 | $0.00 | 353,124 |
| Vizirgianakis Stavros G. | Director | 08/15/2024 | AA | Direct | COM | 505,405 | $0.00 | $0.00 | 6,961,773 |
| Vizirgianakis Stavros G. | Director | 08/15/2024 | AA | Direct | COM | 243,243 | $0.00 | $0.00 | 6,456,368 |
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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust |
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