| Transactions | |||
| All | Buy | Sell | Option Exercise |
Filer's Name |
Relationship/ Title |
Trans. Date |
Trans. Type |
Ownership Type |
Security Type |
Shares |
Price |
Trans. Value |
Total Shares Owned |
| Craig Adam R | Executive Chairman | 10/23/2025 | AP | Direct | COM | 86,206 | $2.90 | $249,997.40 | 376,087 |
| Kirske David | Chief Financial Officer | 08/14/2025 | AA | Direct | COM | 193,254 | $0.00 | $0.00 | 193,254 |
| Craig Adam R | Executive Chairman | 08/14/2025 | AA | Direct | COM | 289,881 | $0.00 | $0.00 | 289,881 |
| Volpone John | President | 08/14/2025 | AA | Direct | COM | 289,881 | $0.00 | $0.00 | 289,881 |
| Wyzga Michael S | Director | 06/09/2025 | AA | Direct | COM | 1,500 | $0.00 | $0.00 | 5,555 |
| Mcgirr David W J | Director | 06/09/2025 | AA | Direct | COM | 1,500 | $0.00 | $0.00 | 4,722 |
| Woods Keith | Director | 06/09/2025 | AA | Direct | COM | 1,500 | $0.00 | $0.00 | 6,000 |
| Bridger Gary | Director | 06/09/2025 | AA | Direct | COM | 1,500 | $0.00 | $0.00 | 4,722 |
| De Craecker Francoise | Director | 06/09/2025 | AA | Direct | COM | 1,500 | $0.00 | $0.00 | 4,722 |
| Stewart Murray | Director | 06/09/2025 | AA | Direct | COM | 1,500 | $0.00 | $0.00 | 7,883 |
| Thoren Natasha Fay | Chief Legal Officer | 05/20/2025 | AA | Direct | COM | 3,333 | $0.00 | $0.00 | 9,462 |
| Baldry Mark | Chief Commercial Officer | 05/16/2025 | AP | Direct | COM | 1,032 | $2.48 | $2,561.42 | 25,337 |
| Dibiase Mary | Chief Operating Officer | 02/12/2025 | AA | Direct | COM | 650,000 | $0.00 | $0.00 | 1,140,980 |
| Baldry Mark | Chief Commercial Officer | 02/12/2025 | AA | Direct | COM | 600,000 | $0.00 | $0.00 | 729,173 |
| Ragan Paula | President and CEO | 02/12/2025 | AA | Direct | COM | 2,250,000 | $0.00 | $0.00 | 3,337,386 |
| Mostafa Adam S. | Chief Financial Officer | 02/12/2025 | AA | Direct | COM | 850,000 | $0.00 | $0.00 | 850,000 |
| Arbet-Engels Christophe | Chief Medical Officer | 02/12/2025 | AA | Direct | COM | 850,000 | $0.00 | $0.00 | 864,207 |
| Arbet-Engels Christophe | Chief Medical Officer | 01/24/2025 | DS | Direct | COM | 11,624 | $0.45 | $5,284.27 | 14,207 |
| Dibiase Mary | Chief Operating Officer | 01/24/2025 | DS | Direct | COM | 22,258 | $0.45 | $10,094.00 | 490,980 |
| Baldry Mark | Chief Commercial Officer | 01/24/2025 | DS | Direct | COM | 29,159 | $0.45 | $13,241.10 | 94,123 |
| Mostafa Adam S. | Chief Financial Officer | 01/24/2025 | DS | Direct | COM | 74,773 | $0.45 | $33,946.94 | 0 |
| Ragan Paula | President and CEO | 01/24/2025 | DS | Direct | COM | 76,473 | $0.45 | $34,718.74 | 1,087,386 |
| Arbet-Engels Christophe | Chief Medical Officer | 01/23/2025 | AA | Direct | COM | 25,831 | $0.00 | $0.00 | 25,831 |
| Dibiase Mary | Chief Operating Officer | 01/23/2025 | AA | Direct | COM | 61,178 | $0.00 | $0.00 | 513,238 |
| Baldry Mark | Chief Commercial Officer | 01/23/2025 | AA | Direct | COM | 74,773 | $0.00 | $0.00 | 123,282 |
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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust |
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