| Transactions | |||
| All | Buy | Sell | Option Exercise |
Filer's Name |
Relationship/ Title |
Trans. Date |
Trans. Type |
Ownership Type |
Security Type |
Shares |
Price |
Trans. Value |
Total Shares Owned |
| Mortimer Ian | PRESIDENT & CEO | 03/13/2026 | DS | Direct | COM | 7,308 | $55.23 | $403,584.30 | 19,923 |
| Difabio Andrea | Chief Legal Officer | 03/13/2026 | DS | Direct | COM | 1,342 | $55.23 | $74,111.95 | 7,301 |
| Kenney Christopher John | Chief Medical Officer | 03/13/2026 | DS | Direct | COM | 1,410 | $55.23 | $77,867.25 | 7,069 |
| Mortimer Ian | PRESIDENT & CEO | 03/12/2026 | AM | Direct | COM | 12,500 | $0.00 | $0.00 | 27,231 |
| Difabio Andrea | Chief Legal Officer | 03/12/2026 | AM | Direct | COM | 3,750 | $0.00 | $0.00 | 8,643 |
| Kenney Christopher John | Chief Medical Officer | 03/12/2026 | AM | Direct | COM | 3,750 | $0.00 | $0.00 | 8,479 |
| Mortimer Ian | PRESIDENT & CEO | 03/10/2026 | DS | Direct | COM | 11,269 | $60.11 | $677,357.05 | 14,731 |
| Difabio Andrea | Chief Legal Officer | 03/10/2026 | DS | Direct | COM | 2,607 | $60.11 | $156,701.56 | 4,893 |
| Kenney Christopher John | Chief Medical Officer | 03/10/2026 | DS | Direct | COM | 2,771 | $60.11 | $166,559.27 | 4,729 |
| Mortimer Ian | PRESIDENT & CEO | 03/09/2026 | AM | Direct | COM | 20,000 | $0.00 | $0.00 | 26,000 |
| Mortimer Ian | PRESIDENT & CEO | 03/09/2026 | DS | Direct | COM | 65,000 | $62.06 | $4,033,900.00 | 6,000 |
| Mortimer Ian | PRESIDENT & CEO | 03/09/2026 | AM | Direct | COM | 65,000 | $9.44 | $613,600.00 | 71,000 |
| Mortimer Ian | PRESIDENT & CEO | 03/09/2026 | DS | Direct | COM | 61,652 | $60.08 | $3,704,052.16 | 6,000 |
| Mortimer Ian | PRESIDENT & CEO | 03/09/2026 | DS | Direct | COM | 43,348 | $59.26 | $2,568,802.48 | 72,652 |
| Mortimer Ian | PRESIDENT & CEO | 03/09/2026 | AM | Direct | COM | 105,000 | $4.75 | $498,750.00 | 111,000 |
| Mortimer Ian | PRESIDENT & CEO | 03/09/2026 | DS | Direct | COM | 2,449 | $61.26 | $150,025.74 | 6,000 |
| Mortimer Ian | PRESIDENT & CEO | 03/09/2026 | DS | Direct | COM | 10,072 | $60.47 | $609,053.84 | 8,449 |
| Mortimer Ian | PRESIDENT & CEO | 03/09/2026 | DS | Direct | COM | 12,479 | $59.50 | $742,500.50 | 18,521 |
| Mortimer Ian | PRESIDENT & CEO | 03/09/2026 | AM | Direct | COM | 25,000 | $3.10 | $77,500.00 | 31,000 |
| Mortimer Ian | PRESIDENT & CEO | 03/09/2026 | DS | Direct | COM | 21,515 | $60.49 | $1,301,442.35 | 6,000 |
| Mortimer Ian | PRESIDENT & CEO | 03/09/2026 | DS | Direct | COM | 31,694 | $59.88 | $1,897,836.72 | 27,515 |
| Mortimer Ian | PRESIDENT & CEO | 03/09/2026 | DS | Direct | COM | 21,791 | $58.81 | $1,281,528.71 | 59,209 |
| Mortimer Ian | PRESIDENT & CEO | 03/09/2026 | AM | Direct | COM | 75,000 | $8.40 | $630,000.00 | 81,000 |
| Difabio Andrea | Chief Legal Officer | 03/09/2026 | AM | Direct | COM | 7,500 | $0.00 | $0.00 | 7,500 |
| Kenney Christopher John | Chief Medical Officer | 03/09/2026 | AM | Direct | COM | 7,500 | $0.00 | $0.00 | 7,500 |
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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust |
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