| Transactions | |||
| All | Buy | Sell | Option Exercise |
Filer's Name |
Relationship/ Title |
Trans. Date |
Trans. Type |
Ownership Type |
Security Type |
Shares |
Price |
Trans. Value |
Total Shares Owned |
| Alam Kamran | CHIEF FINANCIAL OFFICER | 02/04/2026 | DS | Direct | COM | 1,655 | $4.52 | $7,480.60 | 1,442,131 |
| Nolan Sean P. | Chief Executive Officer | 01/26/2026 | DS | Direct | COM | 41,312 | $4.61 | $190,448.32 | 2,908,257 |
| Nagendran Sukumar | President and Head of R&D | 01/26/2026 | DS | Direct | COM | 26,918 | $4.61 | $124,091.98 | 1,317,389 |
| Alam Kamran | CHIEF FINANCIAL OFFICER | 01/26/2026 | DS | Direct | COM | 23,849 | $4.61 | $109,943.89 | 1,443,786 |
| Nolan Sean P. | Chief Executive Officer | 01/23/2026 | DS | Direct | COM | 136,789 | $4.75 | $649,747.75 | 2,949,569 |
| Nagendran Sukumar | President and Head of R&D | 01/23/2026 | DS | Direct | COM | 89,132 | $4.75 | $423,377.00 | 1,344,307 |
| Alam Kamran | CHIEF FINANCIAL OFFICER | 01/23/2026 | DS | Direct | COM | 78,968 | $4.75 | $375,098.00 | 1,467,635 |
| Nolan Sean P. | Chief Executive Officer | 01/12/2026 | AA | Direct | COM | 1,008,000 | $0.00 | $0.00 | 3,086,358 |
| Nagendran Sukumar | President and Head of R&D | 01/12/2026 | AA | Direct | COM | 427,000 | $0.00 | $0.00 | 1,433,439 |
| Nagendran Sukumar | President and Head of R&D | 01/12/2026 | DS | Direct | COM | 200,000 | $4.71 | $942,000.00 | 1,006,439 |
| Nagendran Sukumar | President and Head of R&D | 01/12/2026 | AM | Direct | COM | 88,676 | $1.71 | $151,635.96 | 1,206,439 |
| Nagendran Sukumar | President and Head of R&D | 01/12/2026 | AM | Direct | COM | 111,324 | $0.70 | $77,804.34 | 1,117,763 |
| Alam Kamran | CHIEF FINANCIAL OFFICER | 01/12/2026 | AA | Direct | COM | 359,000 | $0.00 | $0.00 | 1,546,603 |
| Nagendran Sukumar | President and Head of R&D | 12/01/2025 | DS | Direct | COM | 260,047 | $4.51 | $1,172,811.97 | 1,006,439 |
| Nagendran Sukumar | President and Head of R&D | 12/01/2025 | AM | Direct | COM | 260,047 | $1.71 | $444,680.37 | 1,266,486 |
| Nagendran Sukumar | President and Head of R&D | 11/28/2025 | DS | Direct | COM | 110,125 | $4.75 | $523,093.75 | 1,006,439 |
| Nagendran Sukumar | President and Head of R&D | 11/28/2025 | AM | Direct | COM | 39,953 | $1.71 | $68,319.63 | 1,116,564 |
| Nagendran Sukumar | President and Head of R&D | 11/28/2025 | AM | Direct | COM | 70,172 | $0.70 | $49,043.21 | 1,076,611 |
| Nagendran Sukumar | President and Head of R&D | 09/10/2025 | DS | Direct | COM | 200,000 | $3.23 | $646,000.00 | 1,006,439 |
| Nagendran Sukumar | President and Head of R&D | 09/10/2025 | AM | Direct | COM | 41,150 | $0.70 | $28,759.74 | 1,206,439 |
| Alam Kamran | CHIEF FINANCIAL OFFICER | 08/21/2025 | DS | Direct | COM | 54,491 | $2.85 | $155,299.35 | 1,187,603 |
| Nagendran Sukumar | President and Head of R&D | 08/21/2025 | DS | Direct | COM | 57,054 | $2.85 | $162,603.90 | 1,165,289 |
| Sepp-Lorenzino Laura | Director | 06/02/2025 | AA | Direct | COM | 56,623 | $0.00 | $0.00 | 105,843 |
| Long Alison S | Director | 06/02/2025 | AA | Direct | COM | 56,623 | $0.00 | $0.00 | 105,843 |
| Donenberg Phillip B. | Director | 06/02/2025 | AA | Direct | COM | 56,623 | $0.00 | $0.00 | 219,954 |
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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust |
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