| Transactions | |||
| All | Buy | Sell | Option Exercise |
Filer's Name |
Relationship/ Title |
Trans. Date |
Trans. Type |
Ownership Type |
Security Type |
Shares |
Price |
Trans. Value |
Total Shares Owned |
| Column Group Iii Gp, Lp | Other | 02/25/2026 | DS | Indirect | COM | 1,862,545 | $0.56 | $1,047,495.31 | 0 |
| Column Group Iii Gp, Lp | Other | 02/25/2026 | DS | Indirect | COM | 1,649,281 | $0.56 | $927,555.63 | 0 |
| Column Group Iii Gp, Lp | Other | 02/24/2026 | DS | Indirect | COM | 349,212 | $0.62 | $214,870.14 | 1,862,545 |
| Column Group Iii Gp, Lp | Other | 02/24/2026 | DS | Indirect | COM | 309,228 | $0.62 | $190,267.99 | 1,649,281 |
| Column Group Iii Gp, Lp | Other | 02/23/2026 | DS | Indirect | COM | 162,291 | $0.60 | $96,920.19 | 2,211,757 |
| Column Group Iii Gp, Lp | Other | 02/23/2026 | DS | Indirect | COM | 143,709 | $0.60 | $85,823.01 | 1,958,509 |
| Column Group Iii Gp, Lp | Other | 02/20/2026 | DS | Indirect | COM | 277,769 | $0.61 | $170,800.16 | 2,374,048 |
| Column Group Iii Gp, Lp | Other | 02/20/2026 | DS | Indirect | COM | 245,965 | $0.61 | $151,243.88 | 2,102,218 |
| Tingley Whittemore | Chief Medical Officer | 02/17/2026 | DS | Direct | COM | 1,876 | $0.64 | $1,206.46 | 218,618 |
| Tingley Whittemore | Chief Medical Officer | 02/17/2026 | DS | Direct | COM | 1,642 | $0.64 | $1,056.13 | 220,494 |
| Tingley Whittemore | Chief Medical Officer | 02/17/2026 | DS | Direct | COM | 1,642 | $0.64 | $1,056.13 | 222,136 |
| Ali Faraz | Chief Executive Officer | 02/17/2026 | DS | Direct | COM | 5,032 | $0.64 | $3,235.58 | 443,404 |
| Ali Faraz | Chief Executive Officer | 02/17/2026 | DS | Direct | COM | 3,979 | $0.64 | $2,558.89 | 448,436 |
| Ali Faraz | Chief Executive Officer | 02/17/2026 | DS | Direct | COM | 5,851 | $0.64 | $3,762.19 | 452,415 |
| Higa Tomohiro | SVP, Finance | 02/17/2026 | DS | Direct | COM | 2,022 | $0.64 | $1,300.35 | 119,752 |
| Higa Tomohiro | SVP, Finance | 02/17/2026 | DS | Direct | COM | 836 | $0.64 | $537.88 | 121,774 |
| Higa Tomohiro | SVP, Finance | 02/17/2026 | DS | Direct | COM | 611 | $0.64 | $393.12 | 122,610 |
| Column Group Iii Gp, Lp | Other | 02/11/2026 | DS | Indirect | COM | 2,151,458 | $0.68 | $1,464,712.61 | 2,651,817 |
| Column Group Iii Gp, Lp | Other | 02/11/2026 | DS | Indirect | COM | 1,905,115 | $0.68 | $1,297,002.29 | 2,348,183 |
| Column Group Iii Gp, Lp | Other | 02/10/2026 | DS | Indirect | COM | 182,295 | $0.82 | $148,770.95 | 4,803,275 |
| Column Group Iii Gp, Lp | Other | 02/10/2026 | DS | Indirect | COM | 161,422 | $0.82 | $131,736.49 | 4,253,298 |
| Ali Faraz | Chief Executive Officer | 02/03/2026 | AA | Direct | COM | 158,600 | $0.00 | $0.00 | 458,266 |
| Tingley Whittemore | Chief Medical Officer | 02/03/2026 | AA | Direct | COM | 48,750 | $0.00 | $0.00 | 223,778 |
| Higa Tomohiro | SVP, Finance | 02/03/2026 | AA | Direct | COM | 29,250 | $0.00 | $0.00 | 123,221 |
| Ali Faraz | Chief Executive Officer | 11/17/2025 | DS | Direct | COM | 3,126 | $1.33 | $4,157.58 | 299,666 |
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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust |
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