QUODD

Insider Transactions last 24 months for Spyre Therapeutics, Inc. - NSDQ: SYRE

Transactions
All	Buy	Sell	Option Exercise

Filer's Name	Relationship/ Title	Trans. Date	Trans. Type	Ownership Type	Security Type	Shares	Price	Trans. Value	Total Shares Owned
Burrows Scott L	Chief Financial Officer	09/02/2025	DS	Direct	COM	18,428	$16.26	$299,639.28	97,994
Henderson Michael Thomas	Director	01/10/2025	AJ	Direct	COM	105,379	$0.00	$0.00	105,379
Albers Jeffrey W.	Director	11/06/2024	DS	Indirect	COM	6,700	$36.76	$246,312.77	27,360
Albers Jeffrey W.	Director	10/25/2024	DS	Indirect	COM	300	$36.43	$10,929.00	34,060
Burrows Scott L	Chief Financial Officer	09/03/2024	DS	Direct	COM	18,531	$28.17	$522,073.86	116,422
Fairmount Funds Management Llc	Director	04/25/2024	AM	Indirect	COM	3,639,680	$0.00	$0.00	4,018,101
Turtle Cameron	Chief Executive Officer	02/15/2024	AA	Direct	COM	400	$9.82	$3,928.00	746,907
Fairmount Funds Management Llc	Director	12/29/2023	AJ	Indirect	COM	406,038	$0.00	$0.00	406,038
Fairmount Funds Management Llc	Director	12/29/2023	AJ	Indirect	COM	406,038	$0.00	$0.00	406,038
Fairmount Funds Management Llc	Director	12/29/2023	DJ	Indirect	COM	3,435,480	$0.00	$0.00	0
Burrows Scott L	Chief Financial Officer	12/22/2023	AA	Direct	COM	134,953	$0.00	$0.00	134,953

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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security \| D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) \| E = Expiration of short derivative position \| F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. \| G = Gift \| H = Expiration (or cancellation) of long derivative position with value received \| I = Discretionary transaction in accordance with Rule 16b-3(f) \| J = Other \| L = Small acquisition under Rule 16a-6 \| M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 \| O = Exercise of out-of-the-money derivative security \| P = Open market or private purchase \| S = Open market or private sale \| U = Disposition pursuant to a tender of shares in a change of control transaction \| W = Acquisition or disposition by will or the laws of descent and distribution \| X = Exercise of in-the-money or at-the-money derivative security \| Z = Deposit into or withdrawal from voting trust		Send to Excel

Transaction Type Key
First letter: A = Acquired, D = Disposed
Second letter:
A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust

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