QUODD

Insider Transactions last 24 months for Spyre Therapeutics, Inc. - NSDQ: SYRE

Transactions
All	Buy	Sell	Option Exercise

Filer's Name	Relationship/ Title	Trans. Date	Trans. Type	Ownership Type	Security Type	Shares	Price	Trans. Value	Total Shares Owned
Burrows Scott L	Chief Financial Officer	03/03/2026	DS	Direct	COM	200	$41.66	$8,332.00	97,994
Burrows Scott L	Chief Financial Officer	03/03/2026	DS	Direct	COM	2,300	$40.56	$93,288.00	98,194
Burrows Scott L	Chief Financial Officer	03/03/2026	AM	Direct	COM	2,500	$14.50	$36,250.00	100,494
Turtle Cameron	Chief Executive Officer	03/02/2026	DS	Direct	COM	9,100	$42.49	$386,659.00	642,540
Turtle Cameron	Chief Executive Officer	03/02/2026	DS	Direct	COM	5,900	$41.73	$246,207.00	651,640
Turtle Cameron	Chief Executive Officer	02/02/2026	DS	Direct	COM	14,043	$32.87	$461,593.41	657,540
Turtle Cameron	Chief Executive Officer	02/02/2026	DS	Direct	COM	957	$31.82	$30,451.74	671,583
Henderson Michael Thomas	Director	01/21/2026	AJ	Direct	COM	63,227	$0.00	$0.00	168,606
Turtle Cameron	Chief Executive Officer	01/02/2026	DS	Direct	COM	100	$32.39	$3,239.00	671,907
Turtle Cameron	Chief Executive Officer	01/02/2026	DS	Direct	COM	2,191	$31.79	$69,651.89	672,007
Turtle Cameron	Chief Executive Officer	01/02/2026	DS	Direct	COM	12,709	$30.47	$387,243.23	674,198
Turtle Cameron	Chief Executive Officer	12/01/2025	DS	Direct	COM	4,005	$29.83	$119,469.15	686,907
Turtle Cameron	Chief Executive Officer	12/01/2025	DS	Direct	COM	10,995	$28.73	$315,886.35	690,912
Turtle Cameron	Chief Executive Officer	11/03/2025	DS	Direct	COM	16,845	$23.66	$398,552.70	701,907
Turtle Cameron	Chief Executive Officer	11/03/2025	DS	Direct	COM	28,155	$23.13	$651,225.15	718,752
Burrows Scott L	Chief Financial Officer	09/02/2025	DS	Direct	COM	18,428	$16.26	$299,639.28	97,994
Henderson Michael Thomas	Director	01/10/2025	AJ	Direct	COM	105,379	$0.00	$0.00	105,379
Albers Jeffrey W.	Director	11/06/2024	DS	Indirect	COM	6,700	$36.76	$246,312.77	27,360
Albers Jeffrey W.	Director	10/25/2024	DS	Indirect	COM	300	$36.43	$10,929.00	34,060
Burrows Scott L	Chief Financial Officer	09/03/2024	DS	Direct	COM	18,531	$28.17	$522,073.86	116,422
Fairmount Funds Management Llc	Director	04/25/2024	AM	Indirect	COM	3,639,680	$0.00	$0.00	4,018,101

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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security \| D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) \| E = Expiration of short derivative position \| F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. \| G = Gift \| H = Expiration (or cancellation) of long derivative position with value received \| I = Discretionary transaction in accordance with Rule 16b-3(f) \| J = Other \| L = Small acquisition under Rule 16a-6 \| M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 \| O = Exercise of out-of-the-money derivative security \| P = Open market or private purchase \| S = Open market or private sale \| U = Disposition pursuant to a tender of shares in a change of control transaction \| W = Acquisition or disposition by will or the laws of descent and distribution \| X = Exercise of in-the-money or at-the-money derivative security \| Z = Deposit into or withdrawal from voting trust		Send to Excel

Transaction Type Key
First letter: A = Acquired, D = Disposed
Second letter:
A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust

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