| Transactions | |||
| All | Buy | Sell | Option Exercise |
Filer's Name |
Relationship/ Title |
Trans. Date |
Trans. Type |
Ownership Type |
Security Type |
Shares |
Price |
Trans. Value |
Total Shares Owned |
| Neill Andrew R | Chief Financial Officer | 01/25/2026 | DF | Direct | COM | 2,589 | $4.15 | $10,744.35 | 228,224 |
| Deyoung Casi | Chief Business Officer | 01/25/2026 | DF | Direct | COM | 2,286 | $4.15 | $9,486.90 | 73,480 |
| Stout Stephen | See Remarks | 01/25/2026 | DF | Direct | COM | 593 | $4.15 | $2,460.95 | 81,529 |
| Pandite Arundathy N. | Chief Medical Officer | 01/25/2026 | DF | Direct | COM | 3,195 | $4.15 | $13,259.25 | 196,219 |
| Neill Andrew R | Chief Financial Officer | 01/10/2026 | DF | Direct | COM | 6,660 | $4.75 | $31,635.00 | 230,813 |
| Pandite Arundathy N. | Chief Medical Officer | 01/10/2026 | DF | Direct | COM | 6,851 | $4.75 | $32,542.25 | 199,414 |
| Deyoung Casi | Chief Business Officer | 01/10/2026 | DF | Direct | COM | 5,699 | $4.75 | $27,070.25 | 75,766 |
| Stout Stephen | See Remarks | 01/10/2026 | DF | Direct | COM | 4,153 | $4.75 | $19,726.75 | 82,122 |
| Ashiya Mona | Director | 08/25/2025 | AP | Indirect | COM | 1,051,021 | $0.87 | $911,970.92 | 1,051,021 |
| Ashiya Mona | Director | 08/25/2025 | AP | Indirect | COM | 5,255,106 | $0.87 | $4,559,855.48 | 5,255,106 |
| Orbimed Advisors Llc | Director | 08/25/2025 | AP | Indirect | COM | 1,051,021 | $0.87 | $911,970.92 | 1,051,021 |
| Orbimed Advisors Llc | Director | 08/25/2025 | AP | Indirect | COM | 5,255,106 | $0.87 | $4,559,855.48 | 5,255,106 |
| Shukla Abhinav A. | Chief Technical Officer | 08/25/2025 | AA | Direct | COM | 5,122 | $0.87 | $4,444.36 | 81,258 |
| Siegall Clay B | Director | 08/25/2025 | AA | Direct | COM | 128,054 | $0.87 | $111,112.46 | 128,054 |
| Stout Stephen | See Remarks | 08/25/2025 | AA | Direct | COM | 12,805 | $0.87 | $11,110.90 | 86,275 |
| Schreiber Taylor | Chief Executive Officer | 08/25/2025 | AA | Direct | COM | 25,610 | $0.87 | $22,221.80 | 96,612 |
| Neill Andrew R | Chief Financial Officer | 08/25/2025 | AA | Direct | COM | 64,027 | $0.87 | $55,556.23 | 237,473 |
| Pandite Arundathy N. | Chief Medical Officer | 01/25/2025 | DF | Direct | COM | 3,211 | $1.16 | $3,724.76 | 206,265 |
| Deyoung Casi | Chief Business Officer | 01/25/2025 | DF | Direct | COM | 2,297 | $1.16 | $2,664.52 | 81,465 |
| Shukla Abhinav A. | Chief Technical Officer | 01/25/2025 | DF | Direct | COM | 2,261 | $1.16 | $2,622.76 | 73,536 |
| Shukla Abhinav A. | Chief Technical Officer | 01/10/2025 | DF | Direct | COM | 4,830 | $1.19 | $5,747.70 | 74,597 |
| Deyoung Casi | Chief Business Officer | 01/10/2025 | DF | Direct | COM | 5,727 | $1.19 | $6,815.13 | 83,762 |
| Pandite Arundathy N. | Chief Medical Officer | 01/10/2025 | DF | Direct | COM | 6,884 | $1.19 | $8,191.96 | 209,476 |
| Redmile Group, Llc | Director | 12/04/2024 | AJ | Indirect | COM | 1,026,888 | $1.25 | $1,283,610.00 | 5,539,724 |
| Redmile Group, Llc | Director | 12/04/2024 | DJ | Indirect | COM | 1,026,888 | $1.25 | $1,283,610.00 | 4,512,836 |
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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust |
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