| Transactions | |||
| All | Buy | Sell | Option Exercise |
Filer's Name |
Relationship/ Title |
Trans. Date |
Trans. Type |
Ownership Type |
Security Type |
Shares |
Price |
Trans. Value |
Total Shares Owned |
| Li Yang | Exec. Vice President, Research | 03/31/2026 | DG | Direct | COM | 1,666 | $0.00 | $0.00 | 14,425 |
| Tcg Crossover Gp Ii, Llc | Other | 03/24/2026 | AP | Indirect | COM | 53,329 | $24.69 | $1,316,858.33 | 736,547 |
| Tcg Crossover Gp Ii, Llc | Other | 03/24/2026 | AP | Indirect | COM | 53,329 | $24.69 | $1,316,858.33 | 736,554 |
| Tcg Crossover Gp Ii, Llc | Other | 03/23/2026 | AP | Indirect | COM | 7,611 | $24.90 | $189,513.14 | 683,218 |
| Tcg Crossover Gp Ii, Llc | Other | 03/23/2026 | AP | Indirect | COM | 7,612 | $24.90 | $189,538.04 | 683,225 |
| Tcg Crossover Gp Ii, Llc | Other | 03/16/2026 | AP | Indirect | COM | 595 | $24.99 | $14,866.49 | 675,610 |
| Tcg Crossover Gp Ii, Llc | Other | 03/16/2026 | AP | Indirect | COM | 595 | $24.99 | $14,866.49 | 675,613 |
| Tcg Crossover Gp Ii, Llc | Other | 03/13/2026 | AP | Indirect | COM | 17,716 | $24.88 | $440,719.16 | 675,015 |
| Tcg Crossover Gp Ii, Llc | Other | 03/13/2026 | AP | Indirect | COM | 17,717 | $24.88 | $440,744.04 | 675,018 |
| Tcg Crossover Gp Ii, Llc | Other | 03/12/2026 | AP | Indirect | COM | 6,187 | $24.99 | $154,582.81 | 657,299 |
| Tcg Crossover Gp Ii, Llc | Other | 03/12/2026 | AP | Indirect | COM | 6,187 | $24.99 | $154,582.81 | 657,301 |
| Tcg Crossover Gp Ii, Llc | Other | 02/12/2026 | AP | Indirect | COM | 546 | $23.86 | $13,028.93 | 651,112 |
| Tcg Crossover Gp Ii, Llc | Other | 02/12/2026 | AP | Indirect | COM | 547 | $23.86 | $13,052.79 | 651,114 |
| Tcg Crossover Gp Ii, Llc | Other | 02/11/2026 | AP | Indirect | COM | 8,881 | $23.58 | $209,369.58 | 650,563 |
| Tcg Crossover Gp Ii, Llc | Other | 02/11/2026 | AP | Indirect | COM | 8,882 | $23.58 | $209,393.15 | 650,567 |
| Tcg Crossover Gp Ii, Llc | Other | 02/03/2026 | AP | Indirect | COM | 2,177 | $21.94 | $47,763.38 | 641,682 |
| Tcg Crossover Gp Ii, Llc | Other | 02/03/2026 | AP | Indirect | COM | 2,178 | $21.94 | $47,785.32 | 641,685 |
| Tcg Crossover Gp Ii, Llc | Other | 02/02/2026 | AP | Indirect | COM | 365 | $21.38 | $7,803.70 | 639,505 |
| Tcg Crossover Gp Ii, Llc | Other | 02/02/2026 | AP | Indirect | COM | 366 | $21.38 | $7,825.08 | 639,507 |
| Tcg Crossover Gp Ii, Llc | Other | 01/30/2026 | AP | Indirect | COM | 2,135 | $21.39 | $45,667.65 | 639,140 |
| Tcg Crossover Gp Ii, Llc | Other | 01/30/2026 | AP | Indirect | COM | 2,136 | $21.39 | $45,689.04 | 639,141 |
| Kutzkey Tim | Director | 01/20/2026 | AP | Indirect | COM | 9,568 | $19.60 | $187,531.84 | 1,016,658 |
| Kutzkey Tim | Director | 01/20/2026 | AP | Indirect | COM | 8,484 | $19.60 | $166,285.55 | 900,292 |
| Column Group Iii Gp, Lp | Other | 01/20/2026 | AP | Indirect | COM | 9,568 | $19.60 | $187,531.84 | 1,016,658 |
| Column Group Iii Gp, Lp | Other | 01/20/2026 | AP | Indirect | COM | 8,484 | $19.60 | $166,285.55 | 900,292 |
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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust |
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