| Transactions | |||
| All | Buy | Sell | Option Exercise |
Filer's Name |
Relationship/ Title |
Trans. Date |
Trans. Type |
Ownership Type |
Security Type |
Shares |
Price |
Trans. Value |
Total Shares Owned |
| Chauche Thierry | Chief Financial Officer | 02/19/2026 | AA | Direct | COM | 44,000 | $0.00 | $0.00 | 59,688 |
| Happel David | President & CEO | 02/19/2026 | AA | Direct | COM | 128,000 | $0.00 | $0.00 | 805,621 |
| Martins Eduardo Bruno | Chief Medical Officer | 02/19/2026 | AA | Direct | COM | 44,000 | $0.00 | $0.00 | 147,296 |
| Rozek Elizabeth | Chief Legal & Admin. Officer | 02/19/2026 | AA | Direct | COM | 44,000 | $0.00 | $0.00 | 234,959 |
| Rozek Elizabeth | Chief Legal & Admin. Officer | 02/10/2026 | DS | Direct | COM | 2,622 | $5.36 | $14,054.44 | 190,959 |
| Martins Eduardo Bruno | Chief Medical Officer | 02/10/2026 | DS | Direct | COM | 3,640 | $5.36 | $19,511.13 | 103,296 |
| Chauche Thierry | Chief Financial Officer | 02/10/2026 | DS | Direct | COM | 1,312 | $5.36 | $7,032.71 | 15,688 |
| Happel David | President & CEO | 02/10/2026 | DS | Direct | COM | 12,101 | $5.36 | $64,864.99 | 677,621 |
| Kemble George | Executive Chairman | 11/20/2025 | DS | Direct | COM | 37,688 | $7.69 | $289,979.01 | 81,005 |
| Rozek Elizabeth | General Counsel and CCO | 07/21/2025 | DS | Direct | COM | 10,780 | $9.13 | $98,470.99 | 183,726 |
| Martins Eduardo Bruno | Chief Medical Officer | 07/21/2025 | DS | Direct | COM | 8,277 | $9.13 | $75,607.08 | 106,936 |
| Happel David | President & CEO | 07/21/2025 | DS | Direct | COM | 65,478 | $9.13 | $598,115.34 | 689,722 |
| Chauche Thierry | Chief Financial Officer | 02/06/2025 | AA | Direct | COM | 17,000 | $0.00 | $0.00 | 17,000 |
| Rozek Elizabeth | General Counsel and CCO | 02/06/2025 | AA | Direct | COM | 34,000 | $0.00 | $0.00 | 194,506 |
| Happel David | President & CEO | 02/06/2025 | AA | Direct | COM | 116,000 | $0.00 | $0.00 | 755,200 |
| Martins Eduardo Bruno | Chief Medical Officer | 02/06/2025 | AA | Direct | COM | 34,000 | $0.00 | $0.00 | 115,213 |
| Martins Eduardo Bruno | Chief Medical Officer | 07/19/2024 | DS | Direct | COM | 8,357 | $3.10 | $25,910.04 | 81,213 |
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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust |
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