QUODD

Insider Transactions last 24 months for Prime Medicine, Inc. - NSDQ: PRME

Transactions
All	Buy	Sell	Option Exercise

Filer's Name	Relationship/ Title	Trans. Date	Trans. Type	Ownership Type	Security Type	Shares	Price	Trans. Value	Total Shares Owned
Arch Venture Partners X, Llc	Other	08/01/2025	AP	Indirect	COM	3,030,300	$3.30	$9,999,990.00	6,230,300
Arch Venture Partners Xii, Llc	Other	08/01/2025	AP	Indirect	COM	3,030,300	$3.30	$9,999,990.00	6,230,300
Nelsen Robert	Director	08/01/2025	AP	Indirect	COM	3,030,300	$3.30	$9,999,990.00	6,230,300
Gv 2021 Gp, L.L.C.	Other	08/01/2025	AP	Indirect	COM	1,500,000	$3.30	$4,950,000.00	3,262,440
Liu David R.	Other	06/30/2025	AP	Direct	COM	21,000	$2.52	$52,829.70	20,240,945
Liu David R.	Other	06/23/2025	AP	Direct	COM	21,000	$2.16	$45,402.00	20,219,945
Liu David R.	Other	06/16/2025	AP	Direct	COM	21,000	$1.49	$31,195.50	20,198,945
Liu David R.	Other	06/11/2025	AP	Direct	COM	21,000	$1.60	$33,589.50	20,177,945
Reine Allan	Chief Executive Officer	05/21/2025	AP	Direct	COM	125,000	$1.18	$147,150.00	125,000
Lee Ann L.	Chief Technical Officer	05/21/2025	AP	Direct	COM	100,000	$1.13	$113,000.00	100,000
Brudnick Richard	Chief Business Officer	05/20/2025	AP	Direct	COM	20,000	$1.19	$23,790.00	20,000
Gottesdiener Keith Michael	See Remarks	10/08/2024	AG	Indirect	COM	226,925	$0.00	$0.00	682,259
Gottesdiener Keith Michael	See Remarks	10/08/2024	DG	Indirect	COM	226,925	$0.00	$0.00	50,241
Gottesdiener Keith Michael	See Remarks	06/05/2024	AG	Indirect	COM	250,000	$0.00	$0.00	277,166
Gottesdiener Keith Michael	See Remarks	06/05/2024	DG	Direct	COM	250,000	$0.00	$0.00	2,310,837
Arch Venture Partners X, Llc	Other	02/15/2024	AP	Indirect	COM	3,200,000	$6.25	$20,000,000.00	3,200,000
Arch Venture Partners Xii, Llc	Other	02/15/2024	AP	Indirect	COM	3,200,000	$6.25	$20,000,000.00	3,200,000
Nelsen Robert	Director	02/15/2024	AP	Indirect	COM	3,200,000	$6.25	$20,000,000.00	3,200,000
Gottesdiener Keith Michael	See Remarks	11/11/2023	DG	Indirect	COM	5,000	$0.00	$0.00	27,166
Gottesdiener Keith Michael	See Remarks	11/11/2023	DG	Direct	COM	7,500	$0.00	$0.00	2,560,837

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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security \| D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) \| E = Expiration of short derivative position \| F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. \| G = Gift \| H = Expiration (or cancellation) of long derivative position with value received \| I = Discretionary transaction in accordance with Rule 16b-3(f) \| J = Other \| L = Small acquisition under Rule 16a-6 \| M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 \| O = Exercise of out-of-the-money derivative security \| P = Open market or private purchase \| S = Open market or private sale \| U = Disposition pursuant to a tender of shares in a change of control transaction \| W = Acquisition or disposition by will or the laws of descent and distribution \| X = Exercise of in-the-money or at-the-money derivative security \| Z = Deposit into or withdrawal from voting trust		Send to Excel

Transaction Type Key
First letter: A = Acquired, D = Disposed
Second letter:
A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust

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