| Transactions | |||
| All | Buy | Sell | Option Exercise |
Filer's Name |
Relationship/ Title |
Trans. Date |
Trans. Type |
Ownership Type |
Security Type |
Shares |
Price |
Trans. Value |
Total Shares Owned |
| Chou William | PRESIDENT AND CEO | 01/08/2026 | DS | Direct | COM | 4,076 | $18.44 | $75,158.99 | 6,524 |
| Chou William | PRESIDENT AND CEO | 01/08/2026 | AM | Direct | COM | 10,000 | $0.00 | $0.00 | 10,600 |
| Borthwick Kathleen | CFO | 01/08/2026 | DS | Direct | COM | 2,062 | $18.44 | $38,022.04 | 5,402 |
| Borthwick Kathleen | CFO | 01/08/2026 | AM | Direct | COM | 5,000 | $0.00 | $0.00 | 7,464 |
| Lynx1 Capital Management Lp | Other | 09/15/2025 | AP | Indirect | COM | 11,900 | $6.99 | $83,175.05 | 623,704 |
| Lynx1 Capital Management Lp | Other | 09/12/2025 | AP | Indirect | COM | 19,783 | $6.99 | $138,299.00 | 611,804 |
| Lynx1 Capital Management Lp | Other | 09/11/2025 | AP | Indirect | COM | 325 | $6.96 | $2,260.64 | 592,021 |
| Lynx1 Capital Management Lp | Other | 07/24/2025 | AP | Indirect | COM | 66,423 | $5.71 | $379,454.67 | 591,696 |
| Lynx1 Capital Management Lp | Other | 07/23/2025 | AP | Indirect | COM | 49,302 | $5.74 | $283,032.92 | 525,273 |
| Lynx1 Capital Management Lp | Other | 07/22/2025 | AP | Indirect | COM | 13,123 | $5.44 | $71,337.94 | 475,971 |
| Orbimed Advisors Llc | Other | 06/26/2025 | DS | Indirect | COM | 213,257 | $0.33 | $70,374.81 | 6,066,343 |
| Orbimed Advisors Llc | Other | 06/25/2025 | DS | Indirect | COM | 138,800 | $0.33 | $45,804.00 | 6,279,600 |
| Orbimed Advisors Llc | Other | 06/24/2025 | DS | Indirect | COM | 231,600 | $0.35 | $81,060.00 | 6,418,400 |
| Orbimed Advisors Llc | Other | 04/24/2025 | DS | Indirect | COM | 68,195 | $0.32 | $21,822.40 | 6,650,000 |
| Orbimed Advisors Llc | Other | 04/23/2025 | DS | Indirect | COM | 89,328 | $0.34 | $30,371.52 | 6,718,195 |
| Orbimed Advisors Llc | Other | 04/22/2025 | DS | Indirect | COM | 78,049 | $0.34 | $26,536.66 | 6,807,523 |
| Orbimed Advisors Llc | Other | 04/17/2025 | DS | Indirect | COM | 77,090 | $0.33 | $25,439.70 | 6,885,572 |
| Orbimed Advisors Llc | Other | 04/16/2025 | DS | Indirect | COM | 61,638 | $0.33 | $20,340.54 | 6,962,662 |
| Orbimed Advisors Llc | Other | 04/15/2025 | DS | Indirect | COM | 10,326 | $0.38 | $3,923.88 | 7,024,300 |
| Borthwick Kathleen | CFO | 02/11/2025 | DS | Direct | COM | 3,183 | $0.53 | $1,685.72 | 41,283 |
| Borthwick Kathleen | CFO | 02/10/2025 | AM | Direct | COM | 8,000 | $0.00 | $0.00 | 44,466 |
| Orbimed Advisors Llc | Other | 01/14/2025 | DS | Indirect | COM | 79,024 | $0.60 | $47,414.40 | 7,034,626 |
| Orbimed Advisors Llc | Other | 01/13/2025 | DS | Indirect | COM | 17,986 | $0.64 | $11,511.04 | 7,113,650 |
| Orbimed Advisors Llc | Other | 01/10/2025 | DS | Indirect | COM | 126,209 | $0.66 | $83,297.94 | 7,131,636 |
| Orbimed Advisors Llc | Other | 01/08/2025 | DS | Indirect | COM | 75,007 | $0.68 | $51,004.76 | 7,257,845 |
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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust |
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