| Transactions | |||
| All | Buy | Sell | Option Exercise |
Filer's Name |
Relationship/ Title |
Trans. Date |
Trans. Type |
Ownership Type |
Security Type |
Shares |
Price |
Trans. Value |
Total Shares Owned |
| Saccomano Nicholas A | President and CEO | 03/23/2026 | DS | Direct | COM | 86 | $4.16 | $357.46 | 7,333 |
| Leverone Jason A. | Chief Financial Officer | 03/23/2026 | DS | Direct | COM | 301 | $4.16 | $1,251.11 | 16,000 |
| Mathers Edward T | Director | 12/31/2025 | AA | Direct | COM | 3,911 | $0.00 | $0.00 | 15,310 |
| Manke Isaac | Director | 12/31/2025 | AA | Direct | COM | 5,258 | $0.00 | $0.00 | 20,583 |
| Saccomano Nicholas A | President and CEO | 12/22/2025 | DS | Direct | COM | 87 | $2.97 | $258.19 | 7,419 |
| Leverone Jason A. | Chief Financial Officer | 12/22/2025 | DS | Direct | COM | 302 | $2.97 | $896.25 | 16,301 |
| Mathers Edward T | Director | 09/30/2025 | AA | Direct | COM | 4,125 | $0.00 | $0.00 | 11,399 |
| Manke Isaac | Director | 09/30/2025 | AA | Direct | COM | 5,545 | $0.00 | $0.00 | 15,325 |
| Saccomano Nicholas A | President and CEO | 09/22/2025 | DS | Direct | COM | 88 | $2.62 | $230.87 | 3,506 |
| Leverone Jason A. | Chief Financial Officer | 09/22/2025 | DS | Direct | COM | 303 | $2.62 | $794.92 | 12,603 |
| Mathers Edward T | Director | 06/30/2025 | AA | Direct | COM | 4,694 | $0.00 | $0.00 | 7,274 |
| Manke Isaac | Director | 06/30/2025 | AA | Direct | COM | 6,311 | $0.00 | $0.00 | 9,780 |
| Leverone Jason A. | Chief Financial Officer | 06/23/2025 | DS | Direct | COM | 303 | $2.38 | $722.41 | 12,906 |
| Saccomano Nicholas A | President and CEO | 06/23/2025 | DS | Direct | COM | 88 | $2.38 | $209.81 | 3,594 |
| Cormorant Asset Management, Lp | Other | 05/15/2025 | DS | Indirect | COM | 1,813,439 | $1.85 | $3,363,022.63 | 0 |
| Acorn Bioventures, L.P. | Other | 05/15/2025 | AP | Indirect | COM | 1,129,730 | $1.85 | $2,090,000.50 | 1,129,730 |
| Acorn Bioventures, L.P. | Other | 05/15/2025 | AP | Direct | COM | 270,270 | $1.85 | $499,999.50 | 1,709,944 |
| Cormorant Asset Management, Lp | Other | 05/12/2025 | DS | Indirect | COM | 24,300 | $1.99 | $48,235.50 | 1,813,439 |
| Leverone Jason A. | Chief Financial Officer | 04/07/2025 | DS | Direct | COM | 1,844 | $2.67 | $4,925.32 | 13,209 |
| Saccomano Nicholas A | President and CEO | 04/07/2025 | DS | Direct | COM | 516 | $2.67 | $1,378.24 | 3,682 |
| Leverone Jason A. | Chief Financial Officer | 04/04/2025 | DS | Direct | COM | 1,278 | $3.33 | $4,252.67 | 15,053 |
| Saccomano Nicholas A | President and CEO | 04/04/2025 | DS | Direct | COM | 358 | $3.33 | $1,191.28 | 4,198 |
| Mathers Edward T | Director | 03/31/2025 | AA | Direct | COM | 2,580 | $0.00 | $0.00 | 2,580 |
| Manke Isaac | Director | 03/31/2025 | AA | Direct | COM | 3,469 | $0.00 | $0.00 | 3,469 |
| Leonard Braden Michael | Other | 10/07/2024 | AJ | Direct | COM | 102,076 | $0.00 | $0.00 | 102,076 |
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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust |
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