| Transactions | |||
| All | Buy | Sell | Option Exercise |
Filer's Name |
Relationship/ Title |
Trans. Date |
Trans. Type |
Ownership Type |
Security Type |
Shares |
Price |
Trans. Value |
Total Shares Owned |
| Hawryluk P. Kent | President & CEO | 03/13/2026 | AP | Indirect | COM | 18,500 | $28.41 | $525,662.70 | 486,777 |
| Hawryluk P. Kent | President & CEO | 02/26/2026 | AM | Direct | COM | 28,768 | $16.00 | $460,288.00 | 728,274 |
| Hawryluk P. Kent | President & CEO | 02/02/2026 | AA | Direct | COM | 35,250 | $0.00 | $0.00 | 699,506 |
| Bartram Richard | Chief Financial Officer | 02/02/2026 | AA | Direct | COM | 15,000 | $0.00 | $0.00 | 15,000 |
| Azoulay Salomon | Chief Medical Officer | 02/02/2026 | AA | Direct | COM | 15,000 | $0.00 | $0.00 | 15,000 |
| Hawryluk P. Kent | President & CEO | 10/24/2025 | AM | Direct | COM | 182,859 | $3.25 | $594,291.75 | 664,256 |
| Hawryluk P. Kent | President & CEO | 10/20/2025 | AP | Indirect | COM | 20,000 | $13.64 | $272,790.00 | 468,277 |
| Hoerter Steven L. | Director | 10/17/2025 | AP | Indirect | COM | 20,000 | $13.25 | $264,984.00 | 20,000 |
| Heron Patrick J | Director | 09/26/2025 | AP | Indirect | COM | 666,666 | $18.00 | $11,999,988.00 | 5,219,440 |
| Pescovitz Ora H. | Director | 04/08/2025 | AP | Direct | COM | 7,693 | $5.89 | $45,311.77 | 24,329 |
| Orbimed Advisors Llc | Director | 02/18/2025 | AP | Indirect | COM | 94,100 | $10.84 | $1,020,044.00 | 747,887 |
| Orbimed Advisors Llc | Director | 02/18/2025 | AP | Indirect | COM | 49,070 | $10.84 | $531,918.80 | 3,255,000 |
| Gordon Carl L | Director | 02/18/2025 | AP | Indirect | COM | 94,100 | $10.84 | $1,020,044.00 | 747,887 |
| Gordon Carl L | Director | 02/18/2025 | AP | Indirect | COM | 49,070 | $10.84 | $531,918.80 | 3,255,000 |
| Orbimed Advisors Llc | Director | 02/14/2025 | AP | Indirect | COM | 29,540 | $9.85 | $290,969.00 | 3,205,930 |
| Orbimed Advisors Llc | Director | 02/14/2025 | AP | Indirect | COM | 17,962 | $9.90 | $177,823.80 | 3,176,390 |
| Gordon Carl L | Director | 02/14/2025 | AP | Indirect | COM | 29,540 | $9.85 | $290,969.00 | 3,205,930 |
| Gordon Carl L | Director | 02/14/2025 | AP | Indirect | COM | 17,962 | $9.90 | $177,823.80 | 3,176,390 |
| Hawryluk P. Kent | President & CEO | 02/04/2025 | AP | Indirect | COM | 50,000 | $10.69 | $534,500.00 | 448,277 |
| Wellington Biomedical Innovation Master Investors (Cayman) Ii L.P. | Other | 09/16/2024 | AC | Direct | COM | 403,787 | $0.00 | $0.00 | 1,790,122 |
| Wellington Biomedical Innovation Master Investors (Cayman) Ii L.P. | Other | 09/16/2024 | AC | Direct | COM | 1,386,335 | $0.00 | $0.00 | 1,386,335 |
| Gordon Carl L | Director | 09/16/2024 | AP | Indirect | COM | 250,000 | $16.00 | $4,000,000.00 | 653,787 |
| Gordon Carl L | Director | 09/16/2024 | AP | Indirect | COM | 500,000 | $16.00 | $8,000,000.00 | 3,158,428 |
| Gordon Carl L | Director | 09/16/2024 | AC | Indirect | COM | 403,787 | $0.00 | $0.00 | 403,787 |
| Gordon Carl L | Director | 09/16/2024 | AC | Indirect | COM | 2,658,428 | $0.00 | $0.00 | 2,658,428 |
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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust |
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