| Transactions | |||
| All | Buy | Sell | Option Exercise |
Filer's Name |
Relationship/ Title |
Trans. Date |
Trans. Type |
Ownership Type |
Security Type |
Shares |
Price |
Trans. Value |
Total Shares Owned |
| Bienaime Jean Jacques | Director | 03/09/2026 | AP | Direct | COM | 2,000 | $11.21 | $22,420.00 | 7,450 |
| Newton Charles W. | Director | 03/09/2026 | AA | Direct | COM | 13,215 | $0.00 | $0.00 | 13,215 |
| Seehra Jasbir | CHIEF EXECUTIVE OFFICER | 02/19/2026 | DS | Direct | COM | 7,015 | $16.17 | $113,432.55 | 385,708 |
| Regnante Keith | CHIEF FINANCIAL OFFICER | 02/18/2026 | DS | Direct | COM | 4,739 | $16.35 | $77,482.65 | 39,261 |
| Lerner Lorena Raquel | Chief Science Officer | 02/18/2026 | DS | Direct | COM | 3,873 | $16.35 | $63,323.55 | 31,127 |
| Cho Esther | SVP, General Counsel | 02/18/2026 | DS | Direct | COM | 4,745 | $16.35 | $77,580.75 | 39,755 |
| Gordon Carl L | Director | 11/21/2025 | DD | Indirect | COM | 74,465 | $17.75 | $1,321,753.75 | 45,057 |
| Gordon Carl L | Director | 11/21/2025 | DD | Indirect | COM | 140,057 | $17.75 | $2,486,011.75 | 759,155 |
| Orbimed Advisors Llc | Director | 11/21/2025 | DD | Indirect | COM | 74,465 | $17.75 | $1,321,753.75 | 45,057 |
| Orbimed Advisors Llc | Director | 11/21/2025 | DD | Indirect | COM | 140,057 | $17.75 | $2,486,011.75 | 759,155 |
| Knowles Julius | Director | 11/21/2025 | DD | Indirect | COM | 130,494 | $17.75 | $2,316,268.50 | 102,233 |
| Knowles Julius | Director | 11/21/2025 | DD | Indirect | COM | 191,527 | $17.75 | $3,399,604.25 | 150,047 |
| Adar1 Capital Management, Llc | Other | 10/15/2025 | DS | Indirect | COM | 743,358 | $17.75 | $13,194,604.50 | 0 |
| Adar1 Capital Management, Llc | Other | 10/15/2025 | DS | Indirect | COM | 254,669 | $17.75 | $4,520,374.75 | 0 |
| Adar1 Capital Management, Llc | Other | 10/15/2025 | DS | Indirect | COM | 4,391,237 | $17.75 | $77,944,456.75 | 0 |
| Pontifax Management 4 G.P. (2015) Ltd. | Other | 10/15/2025 | DS | Indirect | COM | 155,262 | $17.75 | $2,755,900.50 | 0 |
| Pontifax Management 4 G.P. (2015) Ltd. | Other | 10/15/2025 | DS | Indirect | COM | 1,226,412 | $17.75 | $21,768,813.00 | 0 |
| Pontifax Management 4 G.P. (2015) Ltd. | Other | 10/15/2025 | DS | Indirect | COM | 1,121,045 | $17.75 | $19,898,548.75 | 0 |
| Pontifax Management 4 G.P. (2015) Ltd. | Other | 10/15/2025 | DS | Indirect | COM | 2,284,612 | $17.75 | $40,551,863.00 | 0 |
| Seehra Jasbir | CHIEF EXECUTIVE OFFICER | 09/03/2025 | AA | Direct | COM | 90,500 | $0.00 | $0.00 | 392,723 |
| Adar1 Capital Management, Llc | Other | 06/20/2025 | DX | Indirect | COM | 200 | $70.00 | $14,000.00 | 743,358 |
| Adar1 Capital Management, Llc | Other | 06/20/2025 | DX | Indirect | COM | 1,400 | $70.00 | $98,000.00 | 4,391,237 |
| Adar1 Capital Management, Llc | Other | 06/20/2025 | DX | Indirect | COM | 100 | $60.00 | $6,000.00 | 4,392,637 |
| Bienaime Jean Jacques | Director | 06/04/2025 | AA | Direct | COM | 5,250 | $0.00 | $0.00 | 5,450 |
| Farzan Nima | Director | 06/04/2025 | AA | Direct | COM | 5,250 | $0.00 | $0.00 | 5,250 |
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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust |
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