| Transactions | |||
| All | Buy | Sell | Option Exercise |
Filer's Name |
Relationship/ Title |
Trans. Date |
Trans. Type |
Ownership Type |
Security Type |
Shares |
Price |
Trans. Value |
Total Shares Owned |
| Henderson Jane | Chief Financial Officer | 03/25/2026 | DS | Direct | COM | 2,000 | $85.00 | $170,000.00 | 179,371 |
| Henderson Michael Thomas | Chief Executive Officer | 03/11/2026 | DS | Direct | COM | 3,418 | $75.86 | $259,289.48 | 1,152,987 |
| Henderson Michael Thomas | Chief Executive Officer | 03/11/2026 | DS | Direct | COM | 8,219 | $74.83 | $615,027.77 | 1,156,405 |
| Henderson Michael Thomas | Chief Executive Officer | 03/11/2026 | DS | Direct | COM | 8,363 | $74.29 | $621,287.27 | 1,164,624 |
| Dambkowski Carl | Chief Medical Officer | 03/04/2026 | DS | Direct | COM | 200 | $73.26 | $14,652.00 | 209,773 |
| Dambkowski Carl | Chief Medical Officer | 03/04/2026 | DS | Direct | COM | 2,075 | $71.98 | $149,358.50 | 209,973 |
| Dambkowski Carl | Chief Medical Officer | 03/04/2026 | DS | Direct | COM | 3,225 | $70.33 | $226,814.25 | 212,048 |
| Dambkowski Carl | Chief Medical Officer | 03/04/2026 | AM | Direct | COM | 4,125 | $22.86 | $94,297.50 | 215,273 |
| Henderson Jane | Chief Financial Officer | 03/02/2026 | DS | Direct | COM | 406 | $71.66 | $29,093.96 | 181,371 |
| Henderson Jane | Chief Financial Officer | 03/02/2026 | DS | Direct | COM | 994 | $70.45 | $70,027.30 | 181,777 |
| Henderson Jane | Chief Financial Officer | 03/02/2026 | DS | Direct | COM | 300 | $69.43 | $20,829.00 | 182,771 |
| Henderson Jane | Chief Financial Officer | 03/02/2026 | DS | Direct | COM | 300 | $68.27 | $20,481.00 | 183,071 |
| Henderson Michael Thomas | Chief Executive Officer | 02/11/2026 | DS | Direct | COM | 955 | $64.99 | $62,065.45 | 1,172,987 |
| Henderson Michael Thomas | Chief Executive Officer | 02/11/2026 | DS | Direct | COM | 7,551 | $63.73 | $481,225.23 | 1,173,942 |
| Henderson Michael Thomas | Chief Executive Officer | 02/11/2026 | DS | Direct | COM | 11,494 | $62.96 | $723,662.24 | 1,181,493 |
| Dambkowski Carl | Chief Medical Officer | 02/04/2026 | DS | Direct | COM | 200 | $68.94 | $13,788.00 | 211,148 |
| Dambkowski Carl | Chief Medical Officer | 02/04/2026 | DS | Direct | COM | 100 | $67.88 | $6,788.00 | 211,348 |
| Dambkowski Carl | Chief Medical Officer | 02/04/2026 | DS | Direct | COM | 1,299 | $66.85 | $86,838.15 | 211,448 |
| Dambkowski Carl | Chief Medical Officer | 02/04/2026 | DS | Direct | COM | 1,420 | $65.83 | $93,478.60 | 212,747 |
| Dambkowski Carl | Chief Medical Officer | 02/04/2026 | DS | Direct | COM | 2,481 | $64.88 | $160,967.28 | 214,167 |
| Dambkowski Carl | Chief Medical Officer | 02/04/2026 | AM | Direct | COM | 4,125 | $22.86 | $94,297.50 | 216,648 |
| Henderson Jane | Chief Financial Officer | 02/02/2026 | DS | Direct | COM | 100 | $66.89 | $6,689.00 | 183,371 |
| Henderson Jane | Chief Financial Officer | 02/02/2026 | DS | Direct | COM | 1,108 | $66.15 | $73,294.20 | 183,471 |
| Henderson Jane | Chief Financial Officer | 02/02/2026 | DS | Direct | COM | 792 | $65.21 | $51,646.32 | 184,579 |
| Fairmount Funds Management Llc | Director | 01/22/2026 | DS | Indirect | COM | 1,750,000 | $76.30 | $133,525,000.00 | 298,647 |
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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust |
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