| Transactions | |||
| All | Buy | Sell | Option Exercise |
Filer's Name |
Relationship/ Title |
Trans. Date |
Trans. Type |
Ownership Type |
Security Type |
Shares |
Price |
Trans. Value |
Total Shares Owned |
| Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | 03/05/2026 | DS | Direct | COM | 153 | $326.24 | $49,914.72 | 20,569 |
| Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | 03/05/2026 | DS | Direct | COM | 148 | $324.60 | $48,040.80 | 20,722 |
| Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | 03/05/2026 | DS | Direct | COM | 233 | $323.25 | $75,317.25 | 20,870 |
| Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | 03/05/2026 | DS | Direct | COM | 124 | $321.81 | $39,904.44 | 21,103 |
| Garg Pushkal | EVP Chief R&D | 03/05/2026 | DS | Direct | COM | 500 | $326.08 | $163,040.00 | 18,693 |
| Garg Pushkal | EVP Chief R&D | 03/05/2026 | DS | Direct | COM | 510 | $324.59 | $165,540.90 | 19,193 |
| Garg Pushkal | EVP Chief R&D | 03/05/2026 | DS | Direct | COM | 740 | $323.55 | $239,427.00 | 19,703 |
| Garg Pushkal | EVP Chief R&D | 03/05/2026 | DS | Direct | COM | 654 | $322.33 | $210,803.82 | 20,443 |
| Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | 03/04/2026 | DS | Direct | COM | 57 | $325.67 | $18,563.19 | 21,227 |
| Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | 03/04/2026 | DS | Direct | COM | 75 | $324.88 | $24,366.00 | 21,284 |
| Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | 03/04/2026 | DS | Direct | COM | 210 | $323.84 | $68,006.40 | 21,359 |
| Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | 03/04/2026 | DS | Direct | COM | 96 | $323.01 | $31,008.96 | 21,569 |
| Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | 03/04/2026 | DS | Direct | COM | 79 | $321.82 | $25,423.78 | 21,665 |
| Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | 03/04/2026 | DS | Direct | COM | 59 | $320.81 | $18,927.79 | 21,744 |
| Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | 03/04/2026 | DS | Direct | COM | 28 | $320.01 | $8,960.28 | 21,803 |
| Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | 03/04/2026 | DS | Direct | COM | 29 | $319.03 | $9,251.87 | 21,831 |
| Tanguler Tolga | EVP, Chief Commercial Officer | 03/04/2026 | DS | Direct | COM | 208 | $325.67 | $67,739.36 | 34,297 |
| Tanguler Tolga | EVP, Chief Commercial Officer | 03/04/2026 | DS | Direct | COM | 272 | $324.88 | $88,367.36 | 34,505 |
| Tanguler Tolga | EVP, Chief Commercial Officer | 03/04/2026 | DS | Direct | COM | 767 | $323.84 | $248,385.28 | 34,777 |
| Tanguler Tolga | EVP, Chief Commercial Officer | 03/04/2026 | DS | Direct | COM | 350 | $323.01 | $113,053.50 | 35,544 |
| Tanguler Tolga | EVP, Chief Commercial Officer | 03/04/2026 | DS | Direct | COM | 289 | $321.82 | $93,005.98 | 35,894 |
| Tanguler Tolga | EVP, Chief Commercial Officer | 03/04/2026 | DS | Direct | COM | 215 | $320.81 | $68,974.15 | 36,183 |
| Tanguler Tolga | EVP, Chief Commercial Officer | 03/04/2026 | DS | Direct | COM | 102 | $320.01 | $32,641.02 | 36,398 |
| Tanguler Tolga | EVP, Chief Commercial Officer | 03/04/2026 | DS | Direct | COM | 106 | $319.03 | $33,817.18 | 36,500 |
| Poulton Jeffrey V. | EVP, Chief Financial Officer | 03/04/2026 | DS | Direct | COM | 223 | $325.67 | $72,624.41 | 61,805 |
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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust |
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