| Transactions | |||
| All | Buy | Sell | Option Exercise |
Filer's Name |
Relationship/ Title |
Trans. Date |
Trans. Type |
Ownership Type |
Security Type |
Shares |
Price |
Trans. Value |
Total Shares Owned |
| Ra Capital Management, L.P. | Director | 03/16/2026 | AA | Indirect | COM | 6,060,606 | $3.30 | $19,999,999.80 | 19,103,785 |
| Meisner Derek M | Chief Legal Officer & Corp Sec | 03/06/2026 | DS | Direct | COM | 2,090 | $3.26 | $6,813.40 | 173,999 |
| Meisner Derek M | Chief Legal Officer & Corp Sec | 03/06/2026 | AM | Direct | COM | 2,090 | $1.85 | $3,866.50 | 176,089 |
| Meisner Derek M | Chief Legal Officer & Corp Sec | 02/27/2026 | DS | Direct | COM | 9,406 | $3.01 | $28,311.12 | 173,999 |
| Meisner Derek M | Chief Legal Officer & Corp Sec | 02/27/2026 | AM | Direct | COM | 9,406 | $1.85 | $17,401.10 | 183,405 |
| Meisner Derek M | Chief Legal Officer & Corp Sec | 01/28/2026 | DS | Direct | COM | 2,671 | $3.00 | $8,017.27 | 173,999 |
| Meisner Derek M | Chief Legal Officer & Corp Sec | 01/28/2026 | AM | Direct | COM | 2,671 | $1.85 | $4,941.35 | 176,670 |
| Meisner Derek M | Chief Legal Officer & Corp Sec | 01/26/2026 | DS | Direct | COM | 15,085 | $3.00 | $45,262.54 | 173,999 |
| Meisner Derek M | Chief Legal Officer & Corp Sec | 01/26/2026 | AM | Direct | COM | 15,085 | $1.85 | $27,907.25 | 189,084 |
| Meisner Derek M | Chief Legal Officer & Corp Sec | 01/23/2026 | DS | Direct | COM | 5,633 | $1.90 | $10,717.91 | 173,999 |
| Barton Russell | Chief Operating Officer | 01/22/2026 | DS | Direct | COM | 462 | $1.84 | $850.08 | 205,092 |
| Oconnell Daniel Joseph | Chief Executive Officer | 01/22/2026 | DS | Direct | COM | 2,689 | $1.88 | $5,065.54 | 881,275 |
| Zuga Matt | CFO & Chief Business Officer | 01/22/2026 | DS | Direct | COM | 1,687 | $1.86 | $3,137.82 | 304,924 |
| Siemers Eric | Chief Medical Officer | 01/22/2026 | DS | Direct | COM | 895 | $1.82 | $1,628.90 | 255,371 |
| Meisner Derek M | Chief Legal Officer & Corp Sec | 01/22/2026 | DS | Direct | COM | 1,054 | $1.84 | $1,939.36 | 179,632 |
| Barton Russell | Chief Operating Officer | 01/21/2026 | DS | Direct | COM | 2,315 | $1.81 | $4,180.89 | 205,554 |
| Oconnell Daniel Joseph | Chief Executive Officer | 01/21/2026 | DS | Direct | COM | 9,346 | $1.81 | $16,927.48 | 883,964 |
| Zuga Matt | CFO & Chief Business Officer | 01/21/2026 | DS | Direct | COM | 2,473 | $1.81 | $4,469.21 | 306,611 |
| Siemers Eric | Chief Medical Officer | 01/21/2026 | DS | Direct | COM | 2,331 | $1.80 | $4,203.96 | 256,266 |
| Meisner Derek M | Chief Legal Officer & Corp Sec | 01/21/2026 | DS | Direct | COM | 2,247 | $1.81 | $4,063.25 | 180,686 |
| Oconnell Daniel Joseph | Chief Executive Officer | 01/20/2026 | AA | Direct | COM | 299,800 | $0.00 | $0.00 | 893,310 |
| Doherty James J. | President and CDO | 01/16/2026 | AA | Direct | COM | 166,867 | $0.00 | $0.00 | 220,900 |
| Schacterle Amy | Chief Regulatory Officer | 01/16/2026 | AA | Direct | COM | 84,600 | $0.00 | $0.00 | 92,303 |
| Barton Russell | Chief Operating Officer | 01/16/2026 | AA | Direct | COM | 84,600 | $0.00 | $0.00 | 207,869 |
| Siemers Eric | Chief Medical Officer | 01/16/2026 | AA | Direct | COM | 99,133 | $0.00 | $0.00 | 258,597 |
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Transaction Type Key First letter: A = Acquired, D = Disposed Second letter: A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust |
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