QUODD

Insider: Hecht Peter M

Company Holdings	All	CYCN	IRWD

Company Holdings

All

CYCN

IRWD

	Direct	Indirect Ownership	Total
Shares	6,744,615	0	6,744,615
Value	$11,555,300.13	$0.00	$11,555,300.13

Ticker	Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
CYCN	06/03/2021	AAP	823,170	Direct	COM	$3.28	$2,699,997.60	2,047,698
CYCN	05/06/2021	AAP	302,000	Direct	COM	$2.43	$733,860.00	1,224,528
CYCN	05/05/2021	AAP	398,001	Direct	COM	$2.53	$1,006,942.53	922,528
CYCN	05/04/2021	AAP	300,000	Direct	COM	$2.29	$687,000.00	524,527
IRWD	01/25/2019	DDS	29,551	Direct	COM	$12.23	$361,408.73	4,696,917
IRWD	01/24/2019	DDS	30,000	Direct	COM	$12.70	$381,000.00	4,696,917
IRWD	01/23/2019	DDS	30,000	Direct	COM	$12.66	$379,800.00	4,696,917
IRWD	12/07/2017	DDS	57,405	Direct	COM	$15.00	$861,075.00	4,696,917
IRWD	12/06/2017	DDS	56,000	Direct	COM	$15.24	$853,440.00	4,696,917
IRWD	01/12/2017	DDS	32,994	Direct	COM	$15.50	$511,407.00	4,670,322
IRWD	01/11/2017	DDS	32,993	Direct	COM	$15.84	$522,609.12	4,670,322
IRWD	03/11/2016	DDS	40,000	Direct	COM	$10.66	$426,400.00	4,670,322
IRWD	03/10/2016	DDS	40,000	Direct	COM	$10.63	$425,200.00	4,670,322
IRWD	03/09/2016	DDS	40,000	Direct	COM	$10.87	$434,800.00	4,670,322
IRWD	12/15/2015	DDS	73,418	Direct	COM	$11.07	$812,737.26	0
IRWD	03/17/2015	DDS	113,097	Direct	COM	$15.61	$1,765,444.17	4,141,417
IRWD	03/17/2015	DDS	11,903	Direct	COM	$15.77	$187,710.31	4,254,514
IRWD	03/16/2015	DDS	75,000	Direct	COM	$15.60	$1,170,000.00	4,141,417
IRWD	03/03/2015	DDS	6,200	Direct	COM	$15.71	$97,402.00	4,141,417
IRWD	03/02/2015	DDS	13,908	Direct	COM	$16.00	$222,528.00	4,141,417
IRWD	02/27/2015	DDS	22,934	Direct	COM	$15.34	$351,807.56	4,141,417
IRWD	02/27/2015	DDS	20,400	Direct	COM	$16.06	$327,624.00	4,164,351
IRWD	11/05/2012	AAP	50,000	Direct	COM	$11.65	$582,500.00	72,803

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Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
06/03/2021	AAP	823,170	Direct	COM	$3.28	$2,699,997.60	2,047,698
05/06/2021	AAP	302,000	Direct	COM	$2.43	$733,860.00	1,224,528
05/05/2021	AAP	398,001	Direct	COM	$2.53	$1,006,942.53	922,528
05/04/2021	AAP	300,000	Direct	COM	$2.29	$687,000.00	524,527

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
01/25/2019	DDS	29,551	Direct	COM	$12.23	$361,408.73	4,696,917
01/24/2019	DDS	30,000	Direct	COM	$12.70	$381,000.00	4,696,917
01/23/2019	DDS	30,000	Direct	COM	$12.66	$379,800.00	4,696,917
12/07/2017	DDS	57,405	Direct	COM	$15.00	$861,075.00	4,696,917
12/06/2017	DDS	56,000	Direct	COM	$15.24	$853,440.00	4,696,917
01/12/2017	DDS	32,994	Direct	COM	$15.50	$511,407.00	4,670,322
01/11/2017	DDS	32,993	Direct	COM	$15.84	$522,609.12	4,670,322
03/11/2016	DDS	40,000	Direct	COM	$10.66	$426,400.00	4,670,322
03/10/2016	DDS	40,000	Direct	COM	$10.63	$425,200.00	4,670,322
03/09/2016	DDS	40,000	Direct	COM	$10.87	$434,800.00	4,670,322
12/15/2015	DDS	73,418	Direct	COM	$11.07	$812,737.26	0
03/17/2015	DDS	113,097	Direct	COM	$15.61	$1,765,444.17	4,141,417
03/17/2015	DDS	11,903	Direct	COM	$15.77	$187,710.31	4,254,514
03/16/2015	DDS	75,000	Direct	COM	$15.60	$1,170,000.00	4,141,417
03/03/2015	DDS	6,200	Direct	COM	$15.71	$97,402.00	4,141,417
03/02/2015	DDS	13,908	Direct	COM	$16.00	$222,528.00	4,141,417
02/27/2015	DDS	22,934	Direct	COM	$15.34	$351,807.56	4,141,417
02/27/2015	DDS	20,400	Direct	COM	$16.06	$327,624.00	4,164,351
11/05/2012	AAP	50,000	Direct	COM	$11.65	$582,500.00	72,803

Transaction Type Key
First letter: A = Acquired, D = Disposed
Second letter:
A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust

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