QUODD

Insider: LEIDEN JEFFREY M

Company Holdings	All	VRTX	DGX

Company Holdings

All

VRTX

DGX

	Direct	Indirect Ownership	Total
Shares	81,197	0	81,197
Value	$34,180,803.75	$0.00	$34,180,803.75

Ticker	Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
VRTX	12/03/2025	DDS	4,352	Direct	COM	$444.36	$1,933,854.72	75,197
VRTX	12/03/2025	DDS	7,899	Direct	COM	$445.56	$3,519,478.44	67,298
VRTX	12/03/2025	DDS	2,469	Direct	COM	$443.21	$1,094,285.49	79,549
VRTX	12/03/2025	DDS	4,469	Direct	COM	$440.40	$1,968,147.60	83,338
VRTX	12/03/2025	DDS	2,070	Direct	COM	$455.22	$942,305.40	24,026
VRTX	12/03/2025	DDS	1,152	Direct	COM	$447.05	$515,001.60	66,146
VRTX	12/03/2025	DDS	1,320	Direct	COM	$441.26	$582,463.20	82,018
VRTX	12/03/2025	DDS	15,681	Direct	COM	$452.20	$7,090,948.20	36,456
VRTX	12/03/2025	DDS	2,320	Direct	COM	$448.78	$1,041,169.60	63,826
VRTX	12/03/2025	DDS	10,360	Direct	COM	$453.34	$4,696,602.40	26,096
VRTX	12/03/2025	DDS	5,809	Direct	COM	$451.20	$2,621,020.80	52,137
VRTX	12/03/2025	DDS	5,880	Direct	COM	$449.84	$2,645,059.20	57,946
VRTX	11/14/2025	DDS	21,330	Direct	COM	$441.35	$9,413,995.50	24,066
VRTX	11/14/2025	DDS	32,234	Direct	COM	$440.30	$14,192,630.20	45,396
VRTX	11/14/2025	DDS	40	Direct	COM	$442.00	$17,680.00	24,026
VRTX	11/13/2025	DDS	18,528	Direct	COM	$440.22	$8,156,396.16	25,186
VRTX	11/13/2025	DDS	1,160	Direct	COM	$441.05	$511,618.00	24,026
VRTX	08/30/2024	DDS	3,784	Direct	COM	$499.00	$1,888,216.00	9,994
VRTX	02/15/2024	DDS	4,655	Direct	COM	$419.16	$1,951,189.80	17,896
VRTX	02/14/2024	DDS	4,356	Direct	COM	$419.04	$1,825,338.24	22,551
VRTX	02/13/2024	DDS	737	Direct	COM	$419.13	$308,898.81	26,907
VRTX	02/12/2024	DDS	2,009	Direct	COM	$419.22	$842,212.98	28,291
VRTX	02/12/2024	DDS	647	Direct	COM	$420.39	$271,992.33	27,644
VRTX	01/08/2024	DDS	6,648	Direct	COM	$419.07	$2,785,977.36	2,423
VRTX	12/13/2023	DDS	13,254	Direct	COM	$399.41	$5,293,780.14	9,171

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Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
12/03/2025	DDS	4,352	Direct	COM	$444.36	$1,933,854.72	75,197
12/03/2025	DDS	7,899	Direct	COM	$445.56	$3,519,478.44	67,298
12/03/2025	DDS	2,469	Direct	COM	$443.21	$1,094,285.49	79,549
12/03/2025	DDS	4,469	Direct	COM	$440.40	$1,968,147.60	83,338
12/03/2025	DDS	2,070	Direct	COM	$455.22	$942,305.40	24,026
12/03/2025	DDS	1,152	Direct	COM	$447.05	$515,001.60	66,146
12/03/2025	DDS	1,320	Direct	COM	$441.26	$582,463.20	82,018
12/03/2025	DDS	15,681	Direct	COM	$452.20	$7,090,948.20	36,456
12/03/2025	DDS	2,320	Direct	COM	$448.78	$1,041,169.60	63,826
12/03/2025	DDS	10,360	Direct	COM	$453.34	$4,696,602.40	26,096
12/03/2025	DDS	5,809	Direct	COM	$451.20	$2,621,020.80	52,137
12/03/2025	DDS	5,880	Direct	COM	$449.84	$2,645,059.20	57,946
11/14/2025	DDS	21,330	Direct	COM	$441.35	$9,413,995.50	24,066
11/14/2025	DDS	32,234	Direct	COM	$440.30	$14,192,630.20	45,396
11/14/2025	DDS	40	Direct	COM	$442.00	$17,680.00	24,026
11/13/2025	DDS	18,528	Direct	COM	$440.22	$8,156,396.16	25,186
11/13/2025	DDS	1,160	Direct	COM	$441.05	$511,618.00	24,026
08/30/2024	DDS	3,784	Direct	COM	$499.00	$1,888,216.00	9,994
02/15/2024	DDS	4,655	Direct	COM	$419.16	$1,951,189.80	17,896
02/14/2024	DDS	4,356	Direct	COM	$419.04	$1,825,338.24	22,551
02/13/2024	DDS	737	Direct	COM	$419.13	$308,898.81	26,907
02/12/2024	DDS	2,009	Direct	COM	$419.22	$842,212.98	28,291
02/12/2024	DDS	647	Direct	COM	$420.39	$271,992.33	27,644
01/08/2024	DDS	6,648	Direct	COM	$419.07	$2,785,977.36	2,423
12/13/2023	DDS	13,254	Direct	COM	$399.41	$5,293,780.14	9,171

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
05/29/2018	DDS	1,644	Direct	COM	$105.61	$173,622.84	6,000
08/04/2017	DDS	296	Direct	COM	$106.66	$31,571.06	6,000
07/27/2017	DDS	1,304	Direct	COM	$108.73	$141,782.62	6,296
08/03/2016	DDS	311	Direct	COM	$85.61	$26,625.02	6,027
08/03/2016	DDS	1,206	Direct	COM	$85.62	$103,262.54	6,027
08/03/2016	DDS	800	Direct	COM	$85.66	$68,526.40	6,027
08/03/2016	DDS	718	Direct	COM	$85.65	$61,496.70	6,827
08/03/2016	DDS	1,563	Direct	COM	$85.65	$133,866.26	6,027
08/03/2016	DDS	1,747	Direct	COM	$85.57	$149,485.55	6,027

Transaction Type Key
First letter: A = Acquired, D = Disposed
Second letter:
A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust

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