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Insider: MOTT DAVID M

Company Holdings	All	ARDX	NVAX	MRSN	ADAP	MIRM	TRVI	APPN	RYTM	DERM

Company Holdings

All

ARDX

NVAX

MRSN

ADAP

MIRM

TRVI

APPN

RYTM

DERM

	Direct	Indirect Ownership	Total
Shares	3,487,146	51,093,341	54,580,487
Value	$21,558,083.83	$960,174,953.01	$981,733,036.84

Ticker	Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
ARDX	06/16/2025	AAP	200,000	Direct	COM	$3.63	$725,880.00	2,896,871
ARDX	06/09/2025	AAP	200,000	Direct	COM	$3.69	$737,260.00	2,696,871
ARDX	05/15/2025	AAP	100,000	Direct	COM	$3.29	$329,120.00	2,496,871
ARDX	05/02/2025	AAP	381,377	Direct	COM	$4.22	$1,610,936.45	2,396,871
ARDX	02/24/2025	AAP	77,729	Direct	COM	$5.00	$388,738.27	2,015,494
ARDX	01/21/2025	AAP	199,000	Direct	COM	$4.99	$992,671.70	1,937,765
ARDX	12/19/2024	AAP	213,300	Direct	COM	$4.67	$996,580.26	1,638,765
ARDX	11/13/2024	AAP	215,868	Direct	COM	$4.62	$996,597.80	1,425,465
ARDX	11/17/2022	AAP	567,000	Direct	COM	$1.76	$1,000,641.60	1,166,765
NVAX	09/23/2021	DDS	7,557	Direct	COM	$252.56	$1,908,587.61	51,676
NVAX	09/23/2021	DDS	5,728	Direct	COM	$251.32	$1,439,570.12	59,233
NVAX	09/23/2021	DDS	2,732	Direct	COM	$254.46	$695,193.19	41,200
NVAX	09/23/2021	DDS	7,744	Direct	COM	$253.46	$1,962,805.08	43,932
NVAX	09/23/2021	DDS	1,200	Direct	COM	$255.38	$306,460.20	40,000
ARDX	12/10/2020	AAP	170,000	Direct	COM	$5.89	$1,000,841.00	417,284
ARDX	06/25/2020	AAP	68,373	Direct	COM	$6.96	$476,040.18	247,284
ARDX	06/25/2020	AAP	68,373	Direct	COM	$6.96	$476,040.18	247,284
ARDX	06/24/2020	AAP	72,598	Direct	COM	$6.75	$489,862.26	178,911
ARDX	06/24/2020	AAP	72,598	Direct	COM	$6.75	$489,862.26	178,911
ARDX	06/22/2020	AAP	4,673	Direct	COM	$6.75	$31,524.99	106,313
MRSN	04/07/2020	AAP	538,599	Direct	COM	$5.59	$3,010,768.41	538,599
ADAP	01/24/2020	AAP	7,500,000	Indirect	COM	$0.67	$5,000,250.00	19,500,000
MIRM	07/22/2019	AAP	450,000	Indirect	COM	$15.00	$6,750,000.00	4,186,243
TRVI	05/09/2019	AAP	1,500,000	Indirect	COM	$10.00	$15,000,000.00	4,438,562
TRVI	05/09/2019	AAP	1,000,000	Indirect	COM	$10.00	$10,000,000.00	2,938,562

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Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
06/16/2025	AAP	200,000	Direct	COM	$3.63	$725,880.00	2,896,871
06/09/2025	AAP	200,000	Direct	COM	$3.69	$737,260.00	2,696,871
05/15/2025	AAP	100,000	Direct	COM	$3.29	$329,120.00	2,496,871
05/02/2025	AAP	381,377	Direct	COM	$4.22	$1,610,936.45	2,396,871
02/24/2025	AAP	77,729	Direct	COM	$5.00	$388,738.27	2,015,494
01/21/2025	AAP	199,000	Direct	COM	$4.99	$992,671.70	1,937,765
12/19/2024	AAP	213,300	Direct	COM	$4.67	$996,580.26	1,638,765
11/13/2024	AAP	215,868	Direct	COM	$4.62	$996,597.80	1,425,465
11/17/2022	AAP	567,000	Direct	COM	$1.76	$1,000,641.60	1,166,765
12/10/2020	AAP	170,000	Direct	COM	$5.89	$1,000,841.00	417,284
06/25/2020	AAP	68,373	Direct	COM	$6.96	$476,040.18	247,284
06/25/2020	AAP	68,373	Direct	COM	$6.96	$476,040.18	247,284
06/24/2020	AAP	72,598	Direct	COM	$6.75	$489,862.26	178,911
06/24/2020	AAP	72,598	Direct	COM	$6.75	$489,862.26	178,911
06/22/2020	AAP	4,673	Direct	COM	$6.75	$31,524.99	106,313
07/18/2016	AAP	763,651	Indirect	COM	$8.73	$6,666,673.23	2,665,520
07/18/2016	AAP	763,650	Indirect	COM	$8.73	$6,666,664.50	2,665,519
01/13/2016	AAP	500,000	Indirect	COM	$10.00	$5,000,000.00	1,901,869
01/13/2016	AAP	500,000	Indirect	COM	$10.00	$5,000,000.00	1,901,869
06/05/2015	AAP	1,401,869	Indirect	COM	$10.70	$14,999,998.30	1,401,869
06/05/2015	AAP	1,401,869	Indirect	COM	$10.70	$14,999,998.30	1,401,869

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
09/23/2021	DDS	7,557	Direct	COM	$252.56	$1,908,587.61	51,676
09/23/2021	DDS	5,728	Direct	COM	$251.32	$1,439,570.12	59,233
09/23/2021	DDS	2,732	Direct	COM	$254.46	$695,193.19	41,200
09/23/2021	DDS	7,744	Direct	COM	$253.46	$1,962,805.08	43,932
09/23/2021	DDS	1,200	Direct	COM	$255.38	$306,460.20	40,000

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
04/07/2020	AAP	538,599	Direct	COM	$5.59	$3,010,768.41	538,599
03/05/2019	AAP	3,750,000	Indirect	COM	$4.00	$15,000,000.00	11,890,138
07/03/2017	AAP	1,000,000	Indirect	COM	$15.00	$15,000,000.00	8,140,138

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
01/24/2020	AAP	7,500,000	Indirect	COM	$0.67	$5,000,250.00	19,500,000
09/07/2018	AAP	3,000,000	Indirect	COM	$1.67	$5,000,100.00	82,978,668
09/07/2018	AAP	12,000,000	Indirect	COM	$1.67	$20,000,400.00	12,000,000
03/27/2018	AAP	6,000,000	Indirect	COM	$1.92	$11,500,200.00	79,978,672
03/26/2018	AAP	571,164	Indirect	COM	$1.90	$1,087,553.37	73,978,672
03/23/2018	AAP	294,090	Indirect	COM	$1.95	$572,357.96	73,407,508
03/22/2018	AAP	869,574	Indirect	COM	$1.90	$1,655,668.90	73,113,418
03/21/2018	AAP	104,844	Indirect	COM	$1.81	$189,820.06	72,243,844
03/27/2017	AAP	12,870,000	Indirect	COM	$0.70	$9,009,000.00	72,139,000

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
07/22/2019	AAP	450,000	Indirect	COM	$15.00	$6,750,000.00	4,186,243

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
05/09/2019	AAP	1,500,000	Indirect	COM	$10.00	$15,000,000.00	4,438,562
05/09/2019	AAP	1,000,000	Indirect	COM	$10.00	$10,000,000.00	2,938,562

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
11/27/2017	DDS	569,620	Indirect	COM	$19.49	$11,101,893.80	0
11/20/2017	DDS	2,820,516	Indirect	COM	$19.49	$54,971,856.84	0

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
10/10/2017	AAP	550,000	Indirect	COM	$17.00	$9,350,000.00	4,909,956

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
10/08/2014	AAP	69,112	Indirect	COM	$16.00	$1,105,792.00	3,502,922

Transaction Type Key
First letter: A = Acquired, D = Disposed
Second letter:
A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust

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