QUODD

Insider: FMR LLC

Company Holdings	All	MTSR	BEAM	SANA	DTIL	ACRS	CHRS	RGNX	GNRC	RARE	INSM	IRWD

Company Holdings

All

MTSR

BEAM

SANA

DTIL

ACRS

CHRS

RGNX

GNRC

RARE

INSM

IRWD

	Direct	Indirect Ownership	Total
Shares		19,059,553	19,059,553
Value	$	$314,106,335.79	$314,106,335.79

Ticker	Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
MTSR	09/02/2025	DDS	268	Indirect	COM	$36.00	$9,648.00	0
BEAM	07/30/2025	DDS	48,374	Indirect	COM	$20.50	$991,667.00	2,073,665
SANA	01/08/2025	DDS	100,000	Indirect	COM	$6.11	$611,000.00	4,732,423
SANA	01/08/2025	DDS	25,000	Indirect	COM	$6.50	$162,500.00	4,707,423
SANA	01/08/2025	DDS	164,912	Indirect	COM	$6.71	$1,106,559.52	4,542,511
SANA	01/08/2025	DDS	1,000	Indirect	COM	$7.26	$7,260.00	4,541,511
BEAM	02/14/2024	DDS	854,323	Indirect	COM	$30.51	$26,065,394.73	1,281,188
BEAM	02/14/2024	DDS	45,677	Indirect	COM	$31.34	$1,431,517.18	1,235,511
BEAM	02/13/2024	DDS	410	Indirect	COM	$30.28	$12,414.80	2,773,068
BEAM	02/13/2024	DDS	1,155	Indirect	COM	$30.93	$35,724.15	2,771,913
BEAM	09/06/2022	DDS	551	Indirect	COM	$54.25	$29,891.75	0
BEAM	08/05/2022	DDS	20,159	Indirect	COM	$60.50	$1,219,619.50	0
BEAM	08/05/2022	DDS	167	Indirect	COM	$61.00	$10,187.00	0
BEAM	04/13/2022	DDS	6,799	Indirect	COM	$50.70	$344,709.30	12,004
BEAM	04/13/2022	DDS	663	Indirect	COM	$50.75	$33,647.25	0
BEAM	04/13/2022	DDS	8,804	Indirect	COM	$50.01	$440,288.04	3,200
BEAM	04/13/2022	DDS	3,200	Indirect	COM	$50.80	$162,560.00	0
DTIL	04/01/2019	AAP	50,000	Indirect	COM	$16.00	$800,000.00	3,738,248
ACRS	10/26/2016	DDS	3,650	Indirect	COM	$21.93	$80,044.50	2,571,454
ACRS	10/26/2016	DDS	100	Indirect	COM	$22.15	$2,215.00	2,571,354
CHRS	08/08/2016	DDS	475	Indirect	COM	$29.89	$14,197.75	461,119
CHRS	08/08/2016	DDS	1,100	Indirect	COM	$29.92	$32,912.00	457,919
CHRS	08/08/2016	DDS	2,100	Indirect	COM	$29.89	$62,769.00	459,019
CHRS	08/08/2016	DDS	1,349	Indirect	COM	$29.84	$40,254.16	456,570
CHRS	08/08/2016	DDS	84,976	Indirect	COM	$29.86	$2,537,383.36	371,594

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Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
09/02/2025	DDS	268	Indirect	COM	$36.00	$9,648.00	0

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
07/30/2025	DDS	48,374	Indirect	COM	$20.50	$991,667.00	2,073,665
02/14/2024	DDS	854,323	Indirect	COM	$30.51	$26,065,394.73	1,281,188
02/14/2024	DDS	45,677	Indirect	COM	$31.34	$1,431,517.18	1,235,511
02/13/2024	DDS	410	Indirect	COM	$30.28	$12,414.80	2,773,068
02/13/2024	DDS	1,155	Indirect	COM	$30.93	$35,724.15	2,771,913
09/06/2022	DDS	551	Indirect	COM	$54.25	$29,891.75	0
08/05/2022	DDS	20,159	Indirect	COM	$60.50	$1,219,619.50	0
08/05/2022	DDS	167	Indirect	COM	$61.00	$10,187.00	0
04/13/2022	DDS	6,799	Indirect	COM	$50.70	$344,709.30	12,004
04/13/2022	DDS	663	Indirect	COM	$50.75	$33,647.25	0
04/13/2022	DDS	8,804	Indirect	COM	$50.01	$440,288.04	3,200
04/13/2022	DDS	3,200	Indirect	COM	$50.80	$162,560.00	0

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
01/08/2025	DDS	100,000	Indirect	COM	$6.11	$611,000.00	4,732,423
01/08/2025	DDS	25,000	Indirect	COM	$6.50	$162,500.00	4,707,423
01/08/2025	DDS	164,912	Indirect	COM	$6.71	$1,106,559.52	4,542,511
01/08/2025	DDS	1,000	Indirect	COM	$7.26	$7,260.00	4,541,511

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
04/01/2019	AAP	50,000	Indirect	COM	$16.00	$800,000.00	3,738,248

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
10/26/2016	DDS	3,650	Indirect	COM	$21.93	$80,044.50	2,571,454
10/26/2016	DDS	100	Indirect	COM	$22.15	$2,215.00	2,571,354
10/13/2015	AAP	335,455	Indirect	COM	$11.00	$3,690,005.00	3,804,279

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
08/08/2016	DDS	475	Indirect	COM	$29.89	$14,197.75	461,119
08/08/2016	DDS	1,100	Indirect	COM	$29.92	$32,912.00	457,919
08/08/2016	DDS	2,100	Indirect	COM	$29.89	$62,769.00	459,019
08/08/2016	DDS	1,349	Indirect	COM	$29.84	$40,254.16	456,570
08/08/2016	DDS	84,976	Indirect	COM	$29.86	$2,537,383.36	371,594
08/08/2016	DDS	10,000	Indirect	COM	$29.87	$298,700.00	361,594
08/05/2016	DDS	25,000	Indirect	COM	$28.78	$719,500.00	461,594
08/04/2016	DDS	200	Indirect	COM	$27.97	$5,594.00	486,794
08/04/2016	DDS	23,200	Indirect	COM	$28.16	$653,312.00	486,994
08/04/2016	DDS	100	Indirect	COM	$27.87	$2,787.00	486,694
08/04/2016	DDS	100	Indirect	COM	$27.95	$2,795.00	486,594

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
05/17/2016	DDS	18,300	Indirect	COM	$12.41	$227,103.00	619,376
05/16/2016	DDS	900	Indirect	COM	$11.91	$10,719.00	643,887
05/16/2016	DDS	300	Indirect	COM	$12.11	$3,633.00	647,876
05/16/2016	DDS	3,089	Indirect	COM	$11.79	$36,419.31	644,787
05/16/2016	DDS	600	Indirect	COM	$12.12	$7,272.00	643,287
05/16/2016	DDS	400	Indirect	COM	$11.87	$4,748.00	642,887
05/16/2016	DDS	300	Indirect	COM	$12.12	$3,636.00	639,787
05/16/2016	DDS	2,111	Indirect	COM	$12.02	$25,374.22	637,676
05/16/2016	DDS	2,800	Indirect	COM	$11.69	$32,732.00	640,087
05/13/2016	DDS	900	Indirect	COM	$11.26	$10,134.00	648,706
05/13/2016	DDS	4,100	Indirect	COM	$11.25	$46,125.00	649,606
05/13/2016	DDS	200	Indirect	COM	$11.26	$2,252.00	648,506
05/13/2016	DDS	100	Indirect	COM	$11.25	$1,125.00	648,305
05/13/2016	DDS	101	Indirect	COM	$11.28	$1,139.28	648,405
05/13/2016	DDS	29	Indirect	COM	$11.28	$327.12	648,176
05/13/2016	DDS	100	Indirect	COM	$11.29	$1,129.00	648,205
05/12/2016	DDS	500	Indirect	COM	$10.85	$5,425.00	654,706
05/12/2016	DDS	400	Indirect	COM	$10.93	$4,372.00	654,306
05/12/2016	DDS	3,500	Indirect	COM	$10.83	$37,905.00	656,917
05/12/2016	DDS	1,711	Indirect	COM	$10.86	$18,581.46	655,206
05/12/2016	DDS	100	Indirect	COM	$10.88	$1,088.00	653,806
05/12/2016	DDS	100	Indirect	COM	$11.14	$1,114.00	653,706
05/12/2016	DDS	200	Indirect	COM	$10.89	$2,178.00	654,106
05/12/2016	DDS	200	Indirect	COM	$10.85	$2,170.00	653,906
05/11/2016	DDS	1,300	Indirect	COM	$10.58	$13,754.00	663,560

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
07/01/2014	AAP	27,168	Indirect	COM	$47.04	$1,277,982.72	763,071

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
01/31/2014	AAP	175,000	Indirect	COM	$21.00	$3,675,000.00	3,260,240

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
07/22/2013	DDS	354	Indirect	COM	$11.96	$4,233.95	2,221
07/22/2013	DDS	52,262	Indirect	COM	$11.96	$625,069.20	327,234
07/19/2013	DDS	714	Indirect	COM	$12.06	$8,608.56	2,575
07/19/2013	DDS	105,428	Indirect	COM	$12.06	$1,271,124.31	379,496
07/18/2013	DDS	177	Indirect	COM	$11.85	$2,097.11	3,289
07/18/2013	DDS	26,167	Indirect	COM	$11.85	$310,029.23	484,924
07/17/2013	DDS	225,702	Indirect	COM	$11.66	$2,630,985.64	511,091
07/17/2013	DDS	1,529	Indirect	COM	$11.66	$17,823.40	3,466
07/16/2013	DDS	381	Indirect	COM	$10.65	$4,056.81	4,995
07/16/2013	DDS	56,271	Indirect	COM	$10.65	$599,162.35	736,793
07/15/2013	DDS	326	Indirect	COM	$10.93	$3,563.51	5,376
07/15/2013	DDS	48,146	Indirect	COM	$10.93	$526,283.93	793,064
07/12/2013	DDS	51,181	Indirect	COM	$10.56	$540,230.81	841,210
07/12/2013	DDS	347	Indirect	COM	$10.56	$3,662.69	5,702
07/11/2013	DDS	414	Indirect	COM	$10.89	$4,507.26	6,049
07/11/2013	DDS	61,117	Indirect	COM	$10.89	$665,386.89	892,391
07/09/2013	DDS	288	Indirect	COM	$9.98	$2,873.43	6,463
07/09/2013	DDS	42,537	Indirect	COM	$9.98	$424,400.16	953,508
07/08/2013	DDS	294	Indirect	COM	$10.17	$2,990.72	6,751
07/08/2013	DDS	43,346	Indirect	COM	$10.17	$440,937.19	996,045
07/05/2013	DDS	405	Indirect	COM	$9.92	$4,017.84	7,045
07/05/2013	DDS	59,729	Indirect	COM	$9.92	$592,547.52	1,039,391
07/03/2013	DDS	305	Indirect	COM	$9.96	$3,038.87	7,450
07/03/2013	DDS	45,034	Indirect	COM	$9.96	$448,696.26	1,099,120
07/02/2013	DDS	612	Indirect	COM	$9.90	$6,060.82	7,755

Trans. Date	Trans. Type	Shares	Ownership Type	Issue Type	Price	Trans. Value	Total Shares Owned
03/28/2013	DDS	158,068	Indirect	COM	$18.40	$2,908,530.23	837,736
03/21/2013	DDS	240,100	Indirect	COM	$0.00	$0.00	995,804
10/15/2012	DDS	35,153	Indirect	COM	$13.13	$461,541.31	1,235,904
10/12/2012	DDS	118,220	Indirect	COM	$13.37	$1,580,743.26	1,271,057
10/11/2012	DDS	59,502	Indirect	COM	$13.08	$778,309.96	1,389,277
10/08/2012	DDS	5,878	Indirect	COM	$13.00	$76,432.22	1,448,779
10/05/2012	DDS	12,727	Indirect	COM	$13.02	$165,746.27	1,454,657
10/04/2012	DDS	700	Indirect	COM	$13.00	$9,100.00	1,467,384
10/03/2012	DDS	6,300	Indirect	COM	$13.00	$81,900.00	1,468,084
10/01/2012	DDS	2,100	Indirect	COM	$13.02	$27,332.97	1,474,384
09/27/2012	DDS	43,622	Indirect	COM	$13.24	$577,341.53	1,476,484
09/26/2012	DDS	51,073	Indirect	COM	$13.20	$674,362.78	1,520,106
09/25/2012	DDS	36,056	Indirect	COM	$13.88	$500,633.95	1,571,179
09/24/2012	DDS	80,409	Indirect	COM	$14.09	$1,133,011.06	1,607,235
09/21/2012	DDS	119,221	Indirect	COM	$14.89	$1,775,069.55	1,806,865
09/20/2012	DDS	53,342	Indirect	COM	$13.75	$733,612.53	1,806,865
09/19/2012	DDS	55,878	Indirect	COM	$13.34	$745,378.99	1,860,207
09/18/2012	DDS	49,113	Indirect	COM	$13.53	$664,317.17	1,916,085
09/17/2012	DDS	39,337	Indirect	COM	$13.22	$519,909.26	1,965,198
09/14/2012	DDS	84,925	Indirect	COM	$13.14	$1,115,719.17	2,004,535
09/13/2012	DDS	29,514	Indirect	COM	$13.06	$385,491.21	2,089,460
08/30/2012	DDS	24,100	Indirect	COM	$13.16	$317,119.85	2,118,974
07/31/2012	DDS	5,345	Indirect	COM	$13.09	$69,970.86	2,143,074
07/30/2012	DDS	2,100	Indirect	COM	$13.26	$27,839.07	2,148,419
07/27/2012	DDS	41,419	Indirect	COM	$13.38	$554,012.26	2,150,519

Transaction Type Key
First letter: A = Acquired, D = Disposed
Second letter:
A = Grant, award or other acquisition pursuant to Rule 16b-3(d) C = Conversion of derivative security | D = Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) | E = Expiration of short derivative position | F = Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. | G = Gift | H = Expiration (or cancellation) of long derivative position with value received | I = Discretionary transaction in accordance with Rule 16b-3(f) | J = Other | L = Small acquisition under Rule 16a-6 | M = Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | O = Exercise of out-of-the-money derivative security | P = Open market or private purchase | S = Open market or private sale | U = Disposition pursuant to a tender of shares in a change of control transaction | W = Acquisition or disposition by will or the laws of descent and distribution | X = Exercise of in-the-money or at-the-money derivative security | Z = Deposit into or withdrawal from voting trust

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